Background The ability of a tumor to become dormant in response to suboptimal conditions
has recently been recognized as a key step in tumor progression. Tumor dormancy has …

Once cancer is initiated, with normal cells mutated into malignant ones, a solid tumour
grows, develops and spreads within its microenvironment invading the local tissue; the …

Cancer cell invasion is a major component of metastasis and is responsible for extensive
cell diffusion into and major destruction of tissues. Cells exhibit complex invasion modes …

The role of the immune system in tumor development increasingly includes the idea of
cancer immunoediting. It comprises three phases: elimination, equilibrium, and escape. In …

Mathematical and computational modeling enables biologists to integrate data from
observations and experiments into a theoretical framework. In this review, we describe how …

A systematic understanding of the evolution and growth dynamics of invasive solid tumors in
response to different chemotherapy strategies is crucial for the development of individually …

Development of normal hematopoietic cells is an ordered multi-step process, tightly
regulated by a complex network of intrinsic factors and microenvironmental cues that control …

Disordered jammed packings under confinement have received considerably less attention
than their bulk counterparts and yet arise in a variety of practical situations. In this work, we …

Leukemogenesis is proposed to result from the continuous interplay between inducive bone
marrow (BM) microenvironments and malignant precursor cells. Recent findings point …

In this paper, by using cellular automata formalism, a two-dimensional stochastic agent-
based model for avascular tumor growth is presented. The model is based on biological …