Prominent among cell surface molecules capable of initiating apoptosis are members of the
tumour necrosis factor (TNF) family of ligands and receptors. Death-inducing members of the …

One of the greatest challenges in the management of patients with follicular cell-derived
thyroid cancer is the treatment of tumors that progress despite surgery, radioiodine, and T4 …

We investigated the mechanisms involved in the resistance to cell death observed in
epithelial cancers. Here, we identify that primary epithelial cancer cells from colon, breast …

Primary B cells from B cell chronic lymphocytic leukaemia (B-CLL) were resistant to the
novel selective cytotoxic agent, TNF-related apoptosis-inducing ligand (TRAIL). Low levels …

Tumor necrosis factor–related apoptosis-inducing ligand (TRAIL, Apo2 ligand) effectively
kills multiple myeloma (MM) cells in vitro irrespective of refractoriness to dexamethasone …

Bacterial membrane vesicle (MV) production has been mainly studied in Gram-negative
species. In this study, we show that Listeria monocytogenes, a Gram-positive pathogen that …

TNF-related apoptosis-inducing ligand (TRAIL), a member of the TNF family, selectively
induce apoptosis in various transformed cell lines but not in almost-normal tissues. It is …

TRAIL/APO-2L induces apoptosis in a variety of transformed cells and has potential as an
anti-cancer therapeutic. The physiologic role of TRAIL is presumably more complex than …

In the early phase of an immune response, T cells are activated and acquire effector
functions. Whereas these short term activated T cells are resistant to CD95-mediated …

The ability of the TRAIL ligand to induce cell killing in three ovarian cancer cell lines was
investigated using a glutathione-S-transferase (GST)-TRAIL fusion protein. One of the three …