Epithelial cells are the first line of mucosal defense. In the intestine, a single layer of
epithelial cells must establish a selectively permeable barrier that supports nutrient …

The blood–brain barrier is playing a critical role in controlling the influx and efflux of
biological substances essential for the brain's metabolic activity as well as neuronal function …

Tight junctions (TJs) are intercellular junctions critical for building the epithelial barrier and
maintaining epithelial polarity. The claudin family of membrane proteins play central roles in …

Tight junctions (TJs) play an important role in intestinal barrier function. TJs in intestinal
epithelial cells are composed of different junctional molecules, such as claudin and …

The blood-brain barrier (BBB) allows the brain to selectively import nutrients and energy
critical to neuronal function while simultaneously excluding neurotoxic substances from the …

The gastrointestinal tract is a specialized organ in which dynamic interactions between host
cells and the complex environment occur in addition to food digestion. Together with the …

Tight junction proteins of the blood–brain barrier are vital for maintaining integrity of
endothelial cells lining brain blood vessels. The presence of these protein complexes in the …

Tight junctions are cell-adhesion complexes that seal tissues and are involved in cell
polarity and signaling. Supra-molecular assembly and positioning of tight junctions as …

Mucosal surfaces are lined by epithelial cells. In the intestine, the epithelium establishes a
selectively permeable barrier that supports nutrient absorption and waste secretion while …

The choroid plexus (CP) forming the blood–cerebrospinal fluid (B-CSF) barrier is among the
least studied structures of the central nervous system (CNS) despite its clinical importance …