This is a review of the anatomical characteristics of human cochlea and the importance of
variations in this anatomy to the process of cochlear implantation (CI). Studies of the human …

Hearing loss due to mutations in the connexin gene family, which encodes gap junctional
proteins, is a common form of hereditary deafness. In particular, connexin 26 (Cx26, GJB2) …

The stria vascularis (SV) generates the endocochlear potential (EP) in the inner ear and is
necessary for proper hair cell mechanotransduction and hearing. While channels belonging …

The inner ear is a very complex sensory organ whose development and function depend on
finely balanced interactions among diverse cell types. The many different kinds of inner ear …

Normal development, function and repair of the sensory epithelia in the inner ear are all
dependent on gap junctional intercellular communication. Mutations in the connexin genes …

The stria vascularis (SV) has been shown to play a critical role in the pathogenesis of many
diseases associated with sensorineural hearing loss (SNHL), including age-related hearing …

Background: The endolymphatic sac (ES) is endowed with a multitude of white blood cells
that may trap and process antigens that reach the inner ear from nearby infection-prone …

Intrinsically generated neural activity propagates through the developing auditory system to
promote maturation and refinement of sound processing circuits prior to hearing onset. This …

Background Sensorineural hearing loss is one of the most common sensory deficiencies.
However, the molecular contribution to age-related hearing loss is not fully elucidated …

Age-related hearing loss (presbyacusis) is the most common type of hearing impairment.
One of the most consistent pathological changes seen in presbyacusis is the loss of spiral …