The evolution of genome mining in microbes–a review
Covering: 2006 to 2016 The computational mining of genomes has become an important
part in the discovery of novel natural products as drug leads. Thousands of bacterial …
part in the discovery of novel natural products as drug leads. Thousands of bacterial …
Biologically active secondary metabolites from the fungi
Many Fungi have a well-developed secondary metabolism. The diversity of fungal species
and the diversification of biosynthetic gene clusters underscores a nearly limitless potential …
and the diversification of biosynthetic gene clusters underscores a nearly limitless potential …
[HTML][HTML] The secondary metabolite bioinformatics portal: computational tools to facilitate synthetic biology of secondary metabolite production
Natural products are among the most important sources of lead molecules for drug
discovery. With the development of affordable whole-genome sequencing technologies and …
discovery. With the development of affordable whole-genome sequencing technologies and …
From genomics to metabolomics, moving toward an integrated strategy for the discovery of fungal secondary metabolites
T Hautbergue, EL Jamin, L Debrauwer, O Puel… - Natural Product …, 2018 - pubs.rsc.org
Fungal secondary metabolites are defined by bioactive properties that ensure adaptation of
the fungus to its environment. Although some of these natural products are promising …
the fungus to its environment. Although some of these natural products are promising …
Increasing the production of the bioactive compounds in medicinal mushrooms: an omics perspective
Macroscopic fungi, mainly higher basidiomycetes and some ascomycetes, are considered
medicinal mushrooms and have long been used in different areas due to their …
medicinal mushrooms and have long been used in different areas due to their …
基因组挖掘在天然产物发现中的应用和前景
杨谦， 程伯涛， 汤志军， 刘文 - 合成生物学, 2021 - synbioj.cip.com.cn
天然产物一直以来都是药物先导化合物的重要来源. 在药物发现领域, 基因组数据常用来识别
潜在的药物靶点或寻找先前被忽视的天然产物的生物合成基因簇. 尽管基因组测序发现了微生物 …
潜在的药物靶点或寻找先前被忽视的天然产物的生物合成基因簇. 尽管基因组测序发现了微生物 …
[HTML][HTML] Omics-based strategies to discover novel classes of RiPP natural products
AM Kloosterman, MH Medema… - Current Opinion in …, 2021 - Elsevier
Highlights•As a quickly expanding and diverse class of natural products, RiPPs are an
excellent target to find leads for new drugs.•New gene clusters can be identified using …
excellent target to find leads for new drugs.•New gene clusters can be identified using …
Secondary metabolite arsenal of an opportunistic pathogenic fungus
Aspergillus fumigatus is a versatile fungus able to successfully exploit diverse environments
from mammalian lungs to agricultural waste products. Among its many fitness attributes are …
from mammalian lungs to agricultural waste products. Among its many fitness attributes are …
Using natural products for drug discovery: the impact of the genomics era
Introduction: Evolutionarily selected over billions of years for their interactions with
biomolecules, natural products have been and continue to be a major source of …
biomolecules, natural products have been and continue to be a major source of …
Description of an orthologous cluster of ochratoxin A biosynthetic genes in Aspergillus and Penicillium species. A comparative analysis
J Gil-Serna, M García-Díaz, MT González-Jaén… - International journal of …, 2018 - Elsevier
Ochratoxin A (OTA) is one of the most important mycotoxins due to its toxic properties and
worldwide distribution which is produced by several Aspergillus and Penicillium species …
worldwide distribution which is produced by several Aspergillus and Penicillium species …