Kidney fibrosis, characterized by excessive deposition of extracellular matrix (ECM) that
leads to tissue scarring, is the final common outcome of a wide variety of chronic kidney …

Skin aging is one of the most evident signs of human aging. Modification of the skin during
the life span is characterized by fine lines and wrinkling, loss of elasticity and volume, laxity …

Bone morphogenetic proteins (BMPs) are multi-functional growth factors belonging to the
Transforming Growth Factor-Beta (TGF-β) superfamily. These proteins are essential to many …

Fibroblasts are the most common cell type of the connective tissues found throughout the
body and the principal source of the extensive extracellular matrix (ECM) characteristic of …

Tenascin-C (TNC) is a hexameric, multimodular extracellular matrix protein with several
molecular forms that are created through alternative splicing and protein modifications. It is …

Growth factors are important morphogenetic proteins that instruct cell behavior and guide
tissue repair and renewal. Although their therapeutic potential holds great promise in …

Chronic liver disease when accompanied by underlying fibrosis, is characterized by an
accumulation of extracellular matrix (ECM) proteins and chronic inflammation. Although …

Growth factors (GFs) are critical in tissue repair, but their translation to clinical use has been
modest. Physiologically, GF interactions with extracellular matrix (ECM) components …

The extracellular matrix (ECM) is a complex network of macromolecules surrounding cells
providing structural support and stability to tissues. The understanding of the ECM and the …

Laminin, as a key component of the basement membrane extracellular matrix (ECM),
regulates tissue morphogenesis. Here, we show that multiple laminin isoforms …