The gut–liver axis and the intersection with the microbiome

A Tripathi, J Debelius, DA Brenner, M Karin… - Nature reviews …, 2018 - nature.com
In the past decade, an exciting realization has been that diverse liver diseases—ranging
from nonalcoholic steatohepatitis, alcoholic steatohepatitis and cirrhosis to hepatocellular …

Intestinal barrier and permeability in health, obesity and NAFLD

P Portincasa, L Bonfrate, M Khalil, MD Angelis… - Biomedicines, 2021 - mdpi.com
The largest surface of the human body exposed to the external environment is the gut. At this
level, the intestinal barrier includes luminal microbes, the mucin layer, gastrointestinal …

Liver steatosis, gut-liver axis, microbiome and environmental factors. A never-ending bidirectional cross-talk

A Di Ciaula, J Baj, G Garruti, G Celano… - Journal of clinical …, 2020 - mdpi.com
The prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing worldwide and
parallels comorbidities such as obesity, metabolic syndrome, dyslipidemia, and diabetes …

[HTML][HTML] Understanding the effects of gut microbiota dysbiosis on nonalcoholic fatty liver disease and the possible probiotics role: recent updates

A Khan, Z Ding, M Ishaq, AS Bacha, I Khan… - … journal of biological …, 2021 - ncbi.nlm.nih.gov
Nonalcoholic fatty liver disease (NAFLD) is leading chronic liver syndrome worldwide. Gut
microbiota dysbiosis significantly contributes to the pathogenesis and severity of NAFLD …

[HTML][HTML] Protective effect of acidic polysaccharide from Schisandra chinensis on acute ethanol-induced liver injury through reducing CYP2E1-dependent oxidative …

R Yuan, X Tao, S Liang, Y Pan, L He, J Sun… - Biomedicine & …, 2018 - Elsevier
Aim Schisandra chinensis is a well-known traditional Chinese medicine used mainly as a
recipe for hepatoprotection. Modern researches have revealed that the hepatoprotection is …

Therapeutic potential of genipin in various acute liver injury, fulminant hepatitis, NAFLD and other non-cancer liver diseases: More friend than foe

X Fan, L Lin, B Cui, T Zhao, L Mao, Y Song… - Pharmacological …, 2020 - Elsevier
Genipin is an aglycone derived from the geniposide, the most abundant iridoid glucoside
constituent of Gardenia jasminoides Ellis. For decades, genipin is the focus of studies as a …

Oxidative stress—A key player in the course of alcohol-related liver disease

A Michalak, T Lach, H Cichoż-Lach - Journal of clinical medicine, 2021 - mdpi.com
Oxidative stress is known to be an inseparable factor involved in the presentation of liver
disorders. Free radicals interfere with DNA, proteins, and lipids, which are crucial in liver …

Gut microbiota interacts with inflammatory responses in acute pancreatitis

L Wu, J Hu, X Yi, J Lv, J Yao, W Tang… - Therapeutic …, 2023 - journals.sagepub.com
Acute pancreatitis (AP) is one of the most common acute abdominal conditions, and its
incidence has been increasing for years. Approximately 15–20% of patients develop severe …

Gut microbiota in non‐alcoholic fatty liver disease and alcohol‐related liver disease: Current concepts and perspectives

JP Arab, M Arrese, VH Shah - Hepatology Research, 2020 - Wiley Online Library
The term, gut–liver axis, is used to highlight the close anatomical and functional relationship
between the intestine and the liver. It has been increasingly recognized that the gut–liver …

Targeted treatment of alcoholic liver disease based on inflammatory signalling pathways

B Wen, C Zhang, J Zhou, Z Zhang, Q Che… - Pharmacology & …, 2021 - Elsevier
Targeted therapy is an emerging treatment strategy for alcoholic liver disease (ALD).
Inflammation plays an important role in the occurrence and development of ALD, and is a …