Recent developments in 1, 6-addition reactions of para-quinone methides (p-QMs)

JY Wang, WJ Hao, SJ Tu, B Jiang - Organic Chemistry Frontiers, 2020 - pubs.rsc.org
In recent years, para-quinone methides (p-QMs) have emerged as attractive and versatile
synthons in organic synthesis owing to their high reactivity. Consequently, p-QM chemistry …

Chemodivergent reactions

IP Beletskaya, C Nájera, M Yus - Chemical Society Reviews, 2020 - pubs.rsc.org
An important strategy for the efficient generation of diversity in molecular structures is the
utilization of common starting materials in chemodivergent transformations. The most …

para‐Quinone Methides as Acceptors in 1,6‐Nucleophilic Conjugate Addition Reactions for the Synthesis of Structurally Diverse Molecules

CGS Lima, FP Pauli, DCS Costa… - European Journal of …, 2020 - Wiley Online Library
para‐Quinone methides (p‐QMs) are naturally occurring molecules that have been finding
increasing synthetic applications in the last few years. The presence of two electronically …

Construction of Oxygen‐ and Nitrogen‐based Heterocycles from p‐Quinone Methides

G Singh, R Pandey, YA Pankhade, S Fatma… - The Chemical …, 2021 - Wiley Online Library
In the last few years, there has been an explosive growth in the area of para‐quinone
methide (p‐QM) chemistry. This boom is actually due to the unique reactivity pattern of p …

Asymmetric Synthesis of Dihydrocoumarins through Chiral Phosphoric Acid-Catalyzed Cycloannulation of para-Quinone Methides and Azlactones

ZP Zhang, KX Xie, C Yang, M Li… - The Journal of Organic …, 2018 - ACS Publications
A chiral phosphoric acid-catalyzed approach constructing dihydrocoumarin motifs by the
addition of azlactones to para-quinone methides (p-QMs) was developed. The reaction …

Enantioselective Organocatalytic 1,6-Addition of Azlactones to para-Quinone Methides: An Access to α,α-Disubstituted and β,β-Diaryl-α-amino acid Esters

W Li, X Xu, Y Liu, H Gao, Y Cheng, P Li - Organic letters, 2018 - ACS Publications
This work describes the first enantioselective 1, 6-additions of azlactones to para-quinone
methides. In the presence of a chiral phosphoric acid, 1, 6-adducts were obtained in high …

[4 + 2] Cyclization of para-Quinone Methide Derivatives with Alkynes

GJ Mei, SL Xu, WQ Zheng, CY Bian… - The Journal of Organic …, 2018 - ACS Publications
The first cyclization of para-quinone methide derivatives with alkynes was established by
utilizing the [4+ 2] reaction of ortho-hydroxyphenyl-substituted para-quinone methides with …

1, 6-Conjugated addition-mediated [4+ 1] annulation: an approach to 2, 3-dihydrobenzofurans

L Liu, Z Yuan, R Pan, Y Zeng, A Lin, H Yao… - Organic Chemistry …, 2018 - pubs.rsc.org
A formal 1, 6-conjugated addition-mediated [4+ 1] annulation of ortho-hydroxyphenyl-
substituted para-quinone methides with sulfonium or ammonium bromides has been …

Diastereo‐and Enantioselective Silver‐Catalyzed [3+ 3] Cycloaddition and Kinetic Resolution of Azomethine Imines with Activated Isocyanides

LF Tao, S Zhang, F Huang, WT Wang… - Angewandte Chemie …, 2022 - Wiley Online Library
In contrast to the well‐established [3+ 2] cycloaddition reactions, the catalytic
enantioselective [3+ n](n≥ 3) cycloaddition reaction of activated isocyanides for the …

Triarylmethanes and their Medium‐Ring Analogues by Unactivated Truce–Smiles Rearrangement of Benzanilides

R Abrams, MH Jesani, A Browning… - Angewandte …, 2021 - Wiley Online Library
Intramolecular nucleophilic aromatic substitution (Truce–Smiles rearrangement) of the
anions of 2‐benzyl benzanilides leads to triarylmethanes in an operationally simple manner …