Itch pathogenesis is broadly characterized into histaminergic and nonhistaminergic
pathways and transmitted via 2 main receptor families: G protein–coupled receptors and …

Key Clinical Points Chronic Pruritus Chronic pruritus (itching that persists for more than 6
weeks) may be caused by inflammatory skin diseases, systemic diseases, neuropathic …

Practice Guidelines 1;(3) guideline policies, including the AASLD Policy on the
Development and Use of Practice Guidelines and the American Gastroenterological …

Diabetes mellitus is a widespread endocrine disease with severe impact on health systems
worldwide. Increased serum glucose causes damage to a wide range of cell types, including …

The neurobiology of itch, which is formally known as pruritus, and its interaction with pain
have been illustrated by the complexity of specific mediators, itch-related neuronal pathways …

Chronic itch is a prevalent and debilitating condition for which few effective therapies are
available. We harnessed the natural variation across genetically distinct mouse strains to …

Atopic dermatitis is a chronic inflammatory skin disease characterized by impaired
epidermal barrier function, inflammatory infiltration, extensive pruritus and a clinical course …

Chronic itch is associated with increased stress, anxiety, and other mood disorders. In turn,
stress and anxiety exacerbate itch, leading to a vicious cycle that affects patient behavior …

Chronic pruritus is difficult to treat and requires the evaluation of new therapeutic modalities.
We initiated an open-labelled, two-arm prospective, proof-of-concept study applying two …

British Association of Dermatologists’ guidelines for the investigation and management of
generalized pruritus in adults without an underlying dermatosis, 2018 | British Journal of …