Propofol is an intravenous hypnotic drug that is used for induction and maintenance of
sedation and general anaesthesia. It exerts its effects through potentiation of the inhibitory …

Propofol is an intravenous agent used commonly for the induction and maintenance of
anesthesia, procedural, and critical care sedation in children. The mechanisms of action on …

Anaesthesiologists must be prepared to deal with pharmacokinetic and pharmacodynamic
(PD) differences in morbidly obese individuals. As drug administration based on total body …

Background The discrepancy between predicted effect-site concentration and measured
bispectral index is problematic during intravenous anesthesia with target-controlled infusion …

Midazolam, fentanyl, and propofol are commonly used for sedation in modern anesthesia
practice. These agents possess characteristics that have afforded various anesthetics to be …

In this paper, the potential applications of control technology to clinical pharmacology are
discussed, specifically the control of drug dosing. The use of closed-loop control for clinical …

Background The adverse haemodynamic effects of the intravenous anaesthetic propofol are
well known, yet few empirical models have explored the dose–response relationship …

Perioperative pharmacology in morbid obesity : Current Opinion in Anesthesiology
Perioperative pharmacology in morbid obesity : Current Opinion in Anesthesiology Log in or …

Efforts to develop new hypnotic compounds continue, although several have recently failed
in development. Propofol has been reformulated in various presentations with and without …

Background Propofol is a common sedative hypnotic for the induction and maintenance of
anesthesia. Clinicians typically moderate the dose of propofol or choose a different sedative …