Focal adhesion kinase (FAK) is a cytoplasmic tyrosine kinase that plays critical roles in
integrin-mediated signal transductions and also participates in signaling by other cell …

Directional migration is an important component of cell motility. Although the basic
mechanisms of random cell movement are well characterized, no single model explains the …

Hypoxia unleashes the invasive and metastatic potential of tumor cells by largely unknown
mechanisms. The Met tyrosine kinase, a high affinity receptor for hepatocyte growth factor …

Cell adhesion in tumors............................................. 1.1. Invasive carcinoma cells exhibit
reduced intercellular adhesion.................... 1.2. The role of the cell adhesion molecule E …

Cell interaction with adhesive proteins or growth factors in the extracellular matrix initiates
Ras/mitogen-activated protein (MAP) kinase signaling. Evidence is provided that MAP …

In epithelial cells, tyrosine kinases induce the tyrosine phosphorylation and ubiquitination of
the E-cadherin complex, which induces endocytosis of E-cadherin. With a modified yeast 2 …

We have previously shown that Madin-Darby canine kidney (MDCK) epithelial cells grown in
collagen gels in the presence of fibroblasts orfibroblast-conditioned medium (CM) form …

Matrix metalloproteinases (MMP) play a role in a wide range of tumorigenesis, including
early carcinogenesis events, tumor growth and tumor invasion and metastasis. Given that …

Connective tissues within the synovial joints are characterized by their dense extracellular
matrix and sparse cellularity. With injury or disease, however, tissues commonly experience …

E-cadherin and the associated catenin complex have been recognised as performing a key
role in cell adhesion. Loss of cell adhesion is seen as a key step in the cascade leading to …