Tumor tissue processing methodologies in combination with data‐independent acquisition
mass spectrometry (DIA‐MS) have emerged that can comprehensively analyze the …

The proteome provides unique insights into disease biology beyond the genome and
transcriptome. A lack of large proteomic datasets has restricted the identification of new …

The laboratory mouse ranks among the most important experimental systems for biomedical
research and molecular reference maps of such models are essential informational tools …

Dose-response curves are key metrics in pharmacology and biology to assess phenotypic or
molecular actions of bioactive compounds in a quantitative fashion. Yet, it is often unclear …

Abstract The Cancer Genome Atlas (TCGA) and the Cancer Cell Line Encyclopedia (CCLE)
are foundational resources in cancer research, providing extensive molecular and …

The proteome, or collection of proteoforms expressed in a biological system, is dynamic and
heterogeneous. As our appreciation for the complexity of the proteome has evolved, so have …

Kinase inhibitors (KIs) are important cancer drugs but often feature polypharmacology that is
molecularly not understood. This disconnect is particularly apparent in cancer entities such …

Mass spectrometry-based phosphoproteomics is currently the leading methodology for the
study of global kinase signaling. The scientific community is continuously releasing …

Protein kinase inhibitors are amongst the most successful cancer treatments, but targetable
kinases activated by genomic abnormalities are rare in T cell acute lymphoblastic leukemia …

Background The biguanide drug metformin is a safe and widely prescribed drug for type 2
diabetes. Interestingly, hundreds of clinical trials have been set to evaluate the potential role …