Macrophages are innate immune cells that possess unique abilities to polarize toward
different phenotypes. Classically activated macrophages are known to have major roles in …

The vast majority of infection with cryptococcal species occurs with Cryptococcus
neoformans in the severely immunocompromised. A significant exception to this is the …

The opportunistic fungal pathogen Cryptococcus neoformans causes lethal infections in
immunocompromised patients. Macrophages are central to the host response to cryptococci; …

Quorum sensing (QS) is a bacterial communication mechanism in which secreted signaling
molecules impact population function and gene expression. QS-like phenomena have been …

Cryptococcal meningoencephalitis is responsible for upwards of 15% of HIV-related deaths
worldwide and is currently the most common cause of non-viral meningitis in the US …

The Cryptococcus neoformans/Cryptococcus gattii species complex is a group of fungal
pathogens with different phenotypic and genotypic diversity that cause disease in …

Exposure to the mold Aspergillus fumigatus may result in allergic bronchopulmonary
aspergillosis, chronic necrotizing pulmonary aspergillosis, or invasive aspergillosis (IA) …

Cryptococcus is an invasive fungus that seriously endangers human life and health, with a
complex and well-established immune-escaping mechanism that interferes with the function …

The potent immunoregulatory properties of IL-10 can counteract protective immune
responses and, thereby, promote persistent infections, as evidenced by studies of …

The scavenger receptor macrophage receptor with collagenous structure (MARCO)
promotes protective innate immunity against bacterial and parasitic infections; however, its …