Albumin is the main determinant of plasma oncotic pressure and it plays a pivotal role in
modulating the distribution of fluids between compartments. Moreover, it has many other …

The administration of IV fluid to avoid dehydration, maintain an effective circulating volume,
and prevent inadequate tissue perfusion should be considered, along with the maintenance …

Low molecular weight hyperbranched polyglycerols are highly water soluble and
biocompatible polyether polyols, which can be synthesized in a controlled manner with …

The provision of adequate nutrition support for patients with traumatic brain injury (TBI) has
been a clinical challenge for decades. The primary and secondary injuries create unique …

To explore whether routinely administered colloids and crystalloids influence the hemostatic
system, we studied 60 patients undergoing knee replacement surgery during randomized …

As a synthetic polycation, polyethylenimine (PEI) is currently one of the most effective non-
viral gene carriers. For in vivo applications, PEI will enter systemic circulation and interact …

Background. Previous studies have shown that 10–30% haemodilution with crystalloid may
induce a hypercoagulable state demonstrable by using the Thrombelastograph®(TEG) …

Background. Plasma substitutes such as hydroxyethyl starch (HES) and various dextrans
may compromise the haemostatic system, thereby causing potentially dangerous bleeding …

Gelatin solutions are often given in clinical practice once the maximal dose of a median-
weight hydroxyethyl starch (HES) has been reached. Colloids are usually combined with …

Attempts at prehospital fluid replacement should not delay the patient's transfer to hospital.
Before bleeding has been stopped, a strategy of controlled fluid resuscitation should be …