Orexin receptor antagonists as emerging treatments for psychiatric disorders
Y Han, K Yuan, Y Zheng, L Lu - Neuroscience bulletin, 2020 - Springer
Orexins comprise two neuropeptides produced by orexin neurons in the lateral
hypothalamus and are released by extensive projections of these neurons throughout the …
hypothalamus and are released by extensive projections of these neurons throughout the …
Orexin reserve: a mechanistic framework for the role of orexins (hypocretins) in addiction
MH James, G Aston-Jones - Biological psychiatry, 2022 - Elsevier
In 2014, we proposed that orexin signaling transformed motivationally relevant states into
adaptive behavior directed toward exploiting an opportunity or managing a threat, a process …
adaptive behavior directed toward exploiting an opportunity or managing a threat, a process …
A self-congruence and impulse buying effect on user's shopping behaviour over social networking sites: an empirical study
S Chauhan, R Banerjee, C Chakraborty… - International Journal of …, 2021 - emerald.com
Purpose This study aims to investigate the shopping behaviour of consumers, mainly in
fashion apparels, and intends to understand consumer buying patterns in Indian context …
fashion apparels, and intends to understand consumer buying patterns in Indian context …
Role of the orexin system in the bidirectional relation between sleep and epilepsy: New chances for patients with epilepsy by the antagonism to orexin receptors?
C Berteotti, C Calvello, C Liguori - Epilepsia, 2023 - Wiley Online Library
Epilepsy is a common neurological disorder, affecting patients of all ages, reducing the
quality of life, and associated with several comorbidities. Sleep impairment is a frequent …
quality of life, and associated with several comorbidities. Sleep impairment is a frequent …
Pharmacological treatments for cocaine craving: what is the way forward? A systematic review
Background: cocaine craving is a core feature of cocaine use disorder and remains a critical
challenge for abstinence and relapse prevention. This review summarizes the anti-craving …
challenge for abstinence and relapse prevention. This review summarizes the anti-craving …
The neurobiology of binge-eating disorder compared with obesity: implications for differential therapeutics
RG Boswell, MN Potenza, CM Grilo - Clinical therapeutics, 2021 - Elsevier
Purpose Emerging work indicates divergence in the neurobiologies of binge-eating disorder
(BED) and obesity despite their frequent co-occurrence. This review highlights specific …
(BED) and obesity despite their frequent co-occurrence. This review highlights specific …
Sleep dysregulation in binge eating disorder and “food addiction”: the orexin (hypocretin) system as a potential neurobiological link
It has been proposed that binge eating reflects a pathological compulsion driven by the
“addictive” properties of foods. Proponents of this argument highlight the large degree of …
“addictive” properties of foods. Proponents of this argument highlight the large degree of …
Neurobiology of the orexin system and its potential role in the regulation of hedonic tone
MA Katzman, MP Katzman - Brain sciences, 2022 - mdpi.com
Orexin peptides comprise two neuropeptides, orexin A and orexin B, that bind two G-protein
coupled receptors (GPCRs), orexin receptor 1 (OXR1) and orexin receptor 2 (OXR2) …
coupled receptors (GPCRs), orexin receptor 1 (OXR1) and orexin receptor 2 (OXR2) …
Cognitive boosting interventions for impulsivity in addiction: a systematic review and meta‐analysis of cognitive training, remediation and pharmacological …
Aims To evaluate and compare the effects of three cognitive boosting intervention
approaches (computerised cognitive training, cognitive remediation and pharmacological …
approaches (computerised cognitive training, cognitive remediation and pharmacological …
Abuse potential assessment of the new dual orexin receptor antagonist daridorexant in recreational sedative drug users as compared to suvorexant and zolpidem
M Ufer, D Kelsh, KA Schoedel, J Dingemanse - Sleep, 2022 - academic.oup.com
Abstract Study Objectives Abuse potential properties have been reported for the dual orexin
receptor antagonists (DORAs) suvorexant and lemborexant. Daridorexant is a new DORA …
receptor antagonists (DORAs) suvorexant and lemborexant. Daridorexant is a new DORA …