It has long been axiomatic that a protein's structure determines its function. Intrinsically
disordered proteins (IDPs) and disordered protein regions (IDRs) defy this structure …

Huntington's disease (HD) is an incurable neurodegenerative disease characterized by
abnormal motor movements, personality changes, and early death. HD is caused by a …

Huntington's disease is caused by an abnormally long polyglutamine tract in the huntingtin
protein. This leads to the generation and deposition of N-terminal exon1 fragments of the …

Gains or losses of entire chromosomes lead to aneuploidy, a condition tolerated poorly in all
eukaryotes analyzed to date. How aneuploidy affects organismal and cellular physiology is …

Protein misfolding is intimately associated with devastating human neurodegenerative
diseases, including Alzheimer's, Huntington's, and Parkinson's. Although disparate in their …

Simple polyglutamine (polyQ) peptides aggregate in vitro via a nucleated growth pathway
directly yielding amyloid-like aggregates. We show here that the 17-amino-acid flanking …

Huntington's disease is caused by an expanded polyglutamine tract in huntingtin protein,
leading to accumulation of huntingtin in the nuclei of striatal neurons. The 18 amino-acid …

The N-terminal 17 amino acids of huntingtin (NT17) can be phosphorylated on serines 13
and 16; however, the significance of these modifications in Huntington's disease …

Huntington disease is caused by mutational expansion of the CAG trinucleotide within exon
1 of the huntingtin (Htt) gene. Exon 1 spanning N-terminal fragments (NTFs) of the Htt …

In ageing populations, neurodegenerative diseases increase in prevalence, exacting an
enormous toll on individuals and their communities. Multiple complementary experimental …