Alzheimer's disease and its treatment by different approaches: A review
Alzheimer's disease (AD) is a neurodegenerative disorder that impairs mental ability
development and interrupts neurocognitive function. This neuropathological condition is …
development and interrupts neurocognitive function. This neuropathological condition is …
Potential fluid biomarkers for the diagnosis of mild cognitive impairment
Mild cognitive impairment (MCI) is characterized by a level of cognitive impairment that is
lower than normal for a person's age, but a higher function than that that observed in a …
lower than normal for a person's age, but a higher function than that that observed in a …
Genetic analyses of early-onset Alzheimer's disease using next generation sequencing
Alzheimer's disease (AD) is the most common type of neurodegenerative dementia, but the
cause of AD remained poorly understood. Many mutations in the amyloid precursor protein …
cause of AD remained poorly understood. Many mutations in the amyloid precursor protein …
Lipid-based nanocarriers via nose-to-brain pathway for central nervous system disorders
Neurodegenerative disorders are distinguished by the gradual deterioration of the nervous
system's structure and function due to oxidative stress, mitochondrial dysfunction, protein …
system's structure and function due to oxidative stress, mitochondrial dysfunction, protein …
Analysis of 50 neurodegenerative genes in clinically diagnosed early-onset Alzheimer's disease
Alzheimer's disease (AD), Parkinson's disease (PD), frontotemporal dementia (FTD),
amyotrophic lateral sclerosis (ALS), Huntington's disease (HD), and prion diseases have a …
amyotrophic lateral sclerosis (ALS), Huntington's disease (HD), and prion diseases have a …
APP, PSEN1, and PSEN2 Mutations in Asian Patients with Early-Onset Alzheimer Disease
The number of patients with Alzheimer's disease (AD) is rapidly increasing in Asia.
Mutations in the amyloid protein precursor (APP), presenilin-1 (PSEN1), and presenilin-2 …
Mutations in the amyloid protein precursor (APP), presenilin-1 (PSEN1), and presenilin-2 …
Mutations in human DNA methyltransferase DNMT1 induce specific genome-wide epigenomic and transcriptomic changes in neurodevelopment
Abstract DNA methyltransferase type 1 (DNMT1) is a major enzyme involved in maintaining
the methylation pattern after DNA replication. Mutations in DNMT1 have been associated …
the methylation pattern after DNA replication. Mutations in DNMT1 have been associated …
PM2. 5 exposure associated with microbiota gut-brain axis: Multi-omics mechanistic implications from the BAPE study
Recent studies have shown that PM 2.5 may activate the hypothalamus-pituitary-adrenal
(HPA) axis by inducing hormonal changes, potentially explaining the increase in …
(HPA) axis by inducing hormonal changes, potentially explaining the increase in …
Mitochondrial regulation of ferroptosis in cancer therapy
X Cheng, J Zhang, Y Xiao, Z Wang, J He, M Ke… - International Journal of …, 2023 - mdpi.com
Ferroptosis, characterized by glutamate overload, glutathione depletion, and
cysteine/cystine deprivation during iron-and oxidative-damage-dependent cell death, is a …
cysteine/cystine deprivation during iron-and oxidative-damage-dependent cell death, is a …
Actionability of commercial laboratory sequencing panels for newborn screening and the importance of transparency for parental decision-making
DM DeCristo, LV Milko, JM O'Daniel, AKM Foreman… - Genome Medicine, 2021 - Springer
Background Newborn screening aims to identify individual patients who could benefit from
early management, treatment, and/or surveillance practices. As sequencing technologies …
early management, treatment, and/or surveillance practices. As sequencing technologies …