Investigations of apolipoprotein E (APOE) gene, the major genetic risk modifier for
Alzheimer's disease (AD), have yielded significant insights into the pathogenic mechanism …

Background. Alzheimer's disease (AD) is a progressive neurodegenerative disorder
affecting many individuals worldwide with no effective treatment to date. AD is characterized …

Traditional neuroimage analysis pipelines involve computationally intensive, time-
consuming optimization steps, and thus, do not scale well to large cohort studies with …

Thanks to its safety and accessibility, magnetic resonance imaging (MRI) is extensively used
in clinical routine and research field, largely contributing to our understanding of the …

Imaging has played a variety of roles in the study of Alzheimer disease (AD) over the past
four decades. Initially, computed tomography (CT) and then magnetic resonance imaging …

To acquire larger samples for answering complex questions in neuroscience, researchers
have increasingly turned to multi‐site neuroimaging studies. However, these studies are …

Alzheimer's disease (AD) researchers commonly use MRI as a quantitative measure of
disease severity. Historically, hippocampal volume has been favored. Recently,“AD …

Structural imaging based on magnetic resonance is an integral part of the clinical
assessment of patients with suspected Alzheimer dementia. Prospective data on the natural …

The registration of images is a task that is at the core of many applications in computer
vision. In computational neuroimaging where the automated segmentation of brain …

The structure of the brain is constantly changing from birth throughout the lifetime, meaning
that normal aging, free from dementia, is associated with structural brain changes. This …