Mitochondrial dysfunction and biogenesis in neurodegenerative diseases: pathogenesis and treatment
Neurodegenerative diseases are a heterogeneous group of disorders that are incurable and
characterized by the progressive degeneration of the function and structure of the central …
characterized by the progressive degeneration of the function and structure of the central …
PPARγ/PGC1α signaling as a potential therapeutic target for mitochondrial biogenesis in neurodegenerative disorders
S Jamwal, JK Blackburn, JD Elsworth - Pharmacology & Therapeutics, 2021 - Elsevier
Neurodegenerative diseases represent some of the most devastating neurological
disorders, characterized by progressive loss of the structure and function of neurons. Current …
disorders, characterized by progressive loss of the structure and function of neurons. Current …
[HTML][HTML] Protective effects of luteolin against amyloid beta-induced oxidative stress and mitochondrial impairments through peroxisome proliferator-activated receptor γ …
Z He, X Li, Z Wang, Y Cao, S Han, N Li, J Cai, S Cheng… - Redox Biology, 2023 - Elsevier
Alzheimer's disease (AD) is a devastating neurodegenerative disorder characterized by the
deposition of β-amyloid (Aβ) peptides and dysfunction of mitochondrion, which result in …
deposition of β-amyloid (Aβ) peptides and dysfunction of mitochondrion, which result in …
Aberrant insulin signaling in Alzheimer's disease: current knowledge
Alzheimer's disease (AD) is the most common form of dementia affecting elderly people. AD
is a multifaceted pathology characterized by accumulation of extracellular neuritic plaques …
is a multifaceted pathology characterized by accumulation of extracellular neuritic plaques …
Wnt signaling in the nervous system and in Alzheimer's disease
NC Inestrosa, L Varela-Nallar - Journal of molecular cell biology, 2014 - academic.oup.com
Wnts comprise a large family of proteins that have shown to be part of a signaling cascade
that regulates several aspects of development including organogenesis, midbrain …
that regulates several aspects of development including organogenesis, midbrain …
[HTML][HTML] PPARγ as a therapeutic target to rescue mitochondrial function in neurological disease
There is increasing evidence for the involvement of mitochondrial dysfunction and oxidative
stress in the pathogenesis of many of the major neurodegenerative and neuroinflammatory …
stress in the pathogenesis of many of the major neurodegenerative and neuroinflammatory …
Amyloid β-protein assembly and Alzheimer disease
R Roychaudhuri, M Yang, MM Hoshi… - Journal of Biological …, 2009 - ASBMB
The biochemistry of amyloid proteins has been a fascinating and important area of research
because of its contribution to our understanding of protein folding dynamics and assembly …
because of its contribution to our understanding of protein folding dynamics and assembly …
Resveratrol as a therapeutic agent for neurodegenerative diseases
Excess production of reactive oxygen species in the brain has been implicated as a common
underlying risk factor for the pathogenesis of a number of neurodegenerative disorders …
underlying risk factor for the pathogenesis of a number of neurodegenerative disorders …
Activation of Wnt signaling by lithium and rosiglitazone reduced spatial memory impairment and neurodegeneration in brains of an APPswe/PSEN1ΔE9 mouse model …
EM Toledo, NC Inestrosa - Molecular psychiatry, 2010 - nature.com
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by a progressive
deterioration of cognitive abilities, accumulation of the amyloid-β-peptide (Aβ) and synaptic …
deterioration of cognitive abilities, accumulation of the amyloid-β-peptide (Aβ) and synaptic …
PPARγ and oxidative stress: Con (β) catenating NRF2 and FOXO
S Polvani, M Tarocchi, A Galli - PPAR research, 2012 - Wiley Online Library
Peroxisome‐proliferator activator receptor γ (PPARγ) is a nuclear receptor of central
importance in energy homeostasis and inflammation. Recent experimental pieces of …
importance in energy homeostasis and inflammation. Recent experimental pieces of …