Mitochondrial dysfunction and biogenesis in neurodegenerative diseases: pathogenesis and treatment

M Golpich, E Amini, Z Mohamed… - CNS neuroscience & …, 2017 - Wiley Online Library
Neurodegenerative diseases are a heterogeneous group of disorders that are incurable and
characterized by the progressive degeneration of the function and structure of the central …

PPARγ/PGC1α signaling as a potential therapeutic target for mitochondrial biogenesis in neurodegenerative disorders

S Jamwal, JK Blackburn, JD Elsworth - Pharmacology & Therapeutics, 2021 - Elsevier
Neurodegenerative diseases represent some of the most devastating neurological
disorders, characterized by progressive loss of the structure and function of neurons. Current …

[HTML][HTML] Protective effects of luteolin against amyloid beta-induced oxidative stress and mitochondrial impairments through peroxisome proliferator-activated receptor γ …

Z He, X Li, Z Wang, Y Cao, S Han, N Li, J Cai, S Cheng… - Redox Biology, 2023 - Elsevier
Alzheimer's disease (AD) is a devastating neurodegenerative disorder characterized by the
deposition of β-amyloid (Aβ) peptides and dysfunction of mitochondrion, which result in …

Aberrant insulin signaling in Alzheimer's disease: current knowledge

G Bedse, F Di Domenico, G Serviddio… - Frontiers in …, 2015 - frontiersin.org
Alzheimer's disease (AD) is the most common form of dementia affecting elderly people. AD
is a multifaceted pathology characterized by accumulation of extracellular neuritic plaques …

Wnt signaling in the nervous system and in Alzheimer's disease

NC Inestrosa, L Varela-Nallar - Journal of molecular cell biology, 2014 - academic.oup.com
Wnts comprise a large family of proteins that have shown to be part of a signaling cascade
that regulates several aspects of development including organogenesis, midbrain …

[HTML][HTML] PPARγ as a therapeutic target to rescue mitochondrial function in neurological disease

JC Corona, MR Duchen - Free Radical Biology and Medicine, 2016 - Elsevier
There is increasing evidence for the involvement of mitochondrial dysfunction and oxidative
stress in the pathogenesis of many of the major neurodegenerative and neuroinflammatory …

Amyloid β-protein assembly and Alzheimer disease

R Roychaudhuri, M Yang, MM Hoshi… - Journal of Biological …, 2009 - ASBMB
The biochemistry of amyloid proteins has been a fascinating and important area of research
because of its contribution to our understanding of protein folding dynamics and assembly …

Resveratrol as a therapeutic agent for neurodegenerative diseases

AY Sun, Q Wang, A Simonyi, GY Sun - Molecular neurobiology, 2010 - Springer
Excess production of reactive oxygen species in the brain has been implicated as a common
underlying risk factor for the pathogenesis of a number of neurodegenerative disorders …

Activation of Wnt signaling by lithium and rosiglitazone reduced spatial memory impairment and neurodegeneration in brains of an APPswe/PSEN1ΔE9 mouse model …

EM Toledo, NC Inestrosa - Molecular psychiatry, 2010 - nature.com
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by a progressive
deterioration of cognitive abilities, accumulation of the amyloid-β-peptide (Aβ) and synaptic …

PPARγ and oxidative stress: Con (β) catenating NRF2 and FOXO

S Polvani, M Tarocchi, A Galli - PPAR research, 2012 - Wiley Online Library
Peroxisome‐proliferator activator receptor γ (PPARγ) is a nuclear receptor of central
importance in energy homeostasis and inflammation. Recent experimental pieces of …