A novel NAD signaling mechanism in axon degeneration and its relationship to innate immunity
Axon degeneration represents a pathological feature of many neurodegenerative diseases,
including Alzheimer's disease and Parkinson's disease where axons die before the …
including Alzheimer's disease and Parkinson's disease where axons die before the …
Sarm1-dependent axon degeneration: Nucleotide signaling, neurodegenerative disorders, toxicity, and therapeutic opportunities
Axons are an essential component of the nervous system, and axon degeneration is an
early feature of many neurodegenerative disorders. The NAD+ metabolome plays an …
early feature of many neurodegenerative disorders. The NAD+ metabolome plays an …
Multifaceted roles of SARM1 in axon degeneration and signaling
TJ Waller, CA Collins - Frontiers in Cellular Neuroscience, 2022 - frontiersin.org
Axons are considered to be particularly vulnerable components of the nervous system;
impairments to a neuron's axon leads to an effective silencing of a neuron's ability to …
impairments to a neuron's axon leads to an effective silencing of a neuron's ability to …
A phase transition enhances the catalytic activity of SARM1, an NAD+ glycohydrolase involved in neurodegeneration
HS Loring, VL Czech, JD Icso, L O'Connor, SS Parelkar… - Elife, 2021 - elifesciences.org
Sterile alpha and toll/interleukin receptor (TIR) motif–containing protein 1 (SARM1) is a
neuronally expressed NAD+ glycohydrolase whose activity is increased in response to …
neuronally expressed NAD+ glycohydrolase whose activity is increased in response to …
[PDF][PDF] eScholarship@ UMassChan
HS Loring, VL Czech, JD Icso, C Lauren, S Parelkar… - repository.escholarship.umassmed …
Sterile alpha and toll/interleukin receptor (TIR) motif–containing protein 1 (SARM1) is a
neuronally expressed NAD+ glycohydrolase whose activity is increased in response to …
neuronally expressed NAD+ glycohydrolase whose activity is increased in response to …
Shared Regulators of Axon Degeneration and Synaptic Structure
TJ Waller - 2022 - deepblue.lib.umich.edu
The functioning of the nervous system rests on connections between neurons and their
synaptic targets. Often these targets can be a great distance from the neuron, which leaves …
synaptic targets. Often these targets can be a great distance from the neuron, which leaves …