Fluorine in anti-HIV drugs approved by FDA from 1981 to 2023
S Han, Y Lu - European Journal of Medicinal Chemistry, 2023 - Elsevier
Human immunodeficiency virus (HIV) is the etiological agent of acquired immunodeficiency
syndrome (AIDS). Nowadays, FDA has approved over thirty antiretroviral drugs grouped in …
syndrome (AIDS). Nowadays, FDA has approved over thirty antiretroviral drugs grouped in …
HIV-1 drug resistance in people on dolutegravir-based antiretroviral therapy: a collaborative cohort analysis
T Loosli, S Hossmann, SM Ingle, H Okhai… - The Lancet …, 2023 - thelancet.com
Background The widespread use of the integrase strand transfer inhibitor (INSTI)
dolutegravir in first-line and second-line antiretroviral therapy (ART) might facilitate …
dolutegravir in first-line and second-line antiretroviral therapy (ART) might facilitate …
[HTML][HTML] Viral suppression and HIV-1 drug resistance 1 year after pragmatic transitioning to dolutegravir first-line therapy in Malawi: a prospective cohort study
B Schramm, E Temfack, D Descamps, S Nicholas… - The Lancet …, 2022 - thelancet.com
Background Many countries are now replacing non-nucleoside reverse transcriptase
inhibitor (NNRTI)-based first-line antiretroviral therapy (ART) with a regimen containing …
inhibitor (NNRTI)-based first-line antiretroviral therapy (ART) with a regimen containing …
[HTML][HTML] Roadmap for achieving universal antiretroviral treatment
S Sokhela, S Lalla-Edward, MJ Siedner… - Annual review of …, 2023 - annualreviews.org
Modern antiretroviral therapy safely, potently, and durably suppresses human
immunodeficiency virus (HIV) that, if left untreated, predictably causes acquired …
immunodeficiency virus (HIV) that, if left untreated, predictably causes acquired …
Dolutegravir resistance in Malawi's national HIV treatment program
JJ van Oosterhout, C Chipungu… - Open Forum …, 2022 - academic.oup.com
Dolutegravir HIV drug resistance (HIVDR) data from Africa remain sparse. We reviewed
HIVDR results of Malawians on dolutegravir-based antiretroviral therapy (November 2020 …
HIVDR results of Malawians on dolutegravir-based antiretroviral therapy (November 2020 …
[HTML][HTML] Dolutegravir-based regimen ensures high virological success despite prior exposure to efavirenz-based first-line ART in Cameroon: an evidence of a …
ENJ Semengue, J Fokam, NK Etame, E Molimbou… - Viruses, 2022 - mdpi.com
To ensure optimal prescribing practices in the dolutegravir-era in Cameroon, we compared
first-line virological response (VR) under tenofovir+ lamivudine+ dolutegravir (TLD) …
first-line virological response (VR) under tenofovir+ lamivudine+ dolutegravir (TLD) …
[HTML][HTML] HIV-1 diversity and pre-treatment drug resistance in the era of integrase inhibitor among newly diagnosed ART-naïve adult patients in Luanda, Angola
CS Sebastião, AB Abecasis, D Jandondo… - Scientific Reports, 2024 - nature.com
The surveillance of drug resistance in the HIV-1 naïve population remains critical to
optimizing the effectiveness of antiretroviral therapy (ART), mainly in the era of integrase …
optimizing the effectiveness of antiretroviral therapy (ART), mainly in the era of integrase …
Transitioning to dolutegravir in a programmatic setting: Virological outcomes and associated factors among treatment-naïve patients with HIV-1 in the Kilombero and …
AJ Ntamatungiro, A Eichenberger… - Open forum …, 2023 - academic.oup.com
Background Virological outcome data after programmatic transition from non-nucleoside
reverse transcriptase inhibitor (NNRTI)-based to dolutegravir (DTG)-based antiretroviral …
reverse transcriptase inhibitor (NNRTI)-based to dolutegravir (DTG)-based antiretroviral …
[HTML][HTML] Exploring the mechanisms behind HIV drug resistance in sub-Saharan Africa: conceptual mapping of a complex adaptive system based on multi-disciplinary …
A Kiekens, B Dierckx de Casterlé, G Pellizzer… - BMC Public Health, 2022 - Springer
Background HIV drug resistance (HIVDR) continues to threaten the effectiveness of
worldwide antiretroviral therapy (ART). Emergence and transmission of HIVDR are driven by …
worldwide antiretroviral therapy (ART). Emergence and transmission of HIVDR are driven by …
[HTML][HTML] Resistance-informed versus empirical management of viraemia in children and adolescents with HIV in Lesotho and Tanzania (GIVE MOVE trial): a multisite …
JA Brown, IK Ringera, E Luoga, M Bresser… - The Lancet Global …, 2024 - thelancet.com
Background Children and adolescents with HIV taking antiretroviral therapy (ART) have high
rates of viraemia. We assessed if genotypic resistance testing (GRT) to inform onward …
rates of viraemia. We assessed if genotypic resistance testing (GRT) to inform onward …