During liver regeneration after partial hepatectomy, normally quiescent hepatocytes undergo
one or two rounds of replication to restore the liver mass by a process of compensatory …

The unusual regenerative properties of the liver are a logical adaptation by organisms, as
the liver is the main detoxifying organ of the body and is likely to be injured by ingested …

Introduction Mesenchymal stem cell-conditioned medium (MSC-CM) has been shown to
have protective effects against various cellular-injury models. This mechanism of protection …

IL11 is important for fibrosis in non-alcoholic steatohepatitis (NASH) but its role beyond the
stroma in liver disease is unclear. Here, we investigate the role of IL11 in hepatocyte …

The function of the liver as an important constituent of the immune system involved in innate
as well as adaptive immunity is warranted by different highly specialized cell populations. As …

The central role of T cell activation in hepatocellular injury has been well documented. In this
article, we provide evidence suggesting that T cells may also play a protective role in liver …

Genetic analysis in mice has demonstrated a crucial role of the Met tyrosine kinase receptor
and its ligand, hepatocyte growth factor/scatter factor (HGF/SF), in development of the liver …

Acute-phase proteins (APPs) are an evolutionarily conserved family of proteins produced
mainly in the liver in response to infection and inflammation. Despite vast pro-and …

Deregulation of signaling pathways, through mutation or other molecular changes, can
ultimately result in disease. The tyrosine phosphatase Shp2 has emerged as a major …

The capability of the liver to fully regenerate after injury is a unique phenomenon essential
for the maintenance of its important functions in the control of metabolism and xenobiotic …