Histone post-translational modifications—cause and consequence of genome function
G Millán-Zambrano, A Burton, AJ Bannister… - Nature Reviews …, 2022 - nature.com
Much has been learned since the early 1960s about histone post-translational modifications
(PTMs) and how they affect DNA-templated processes at the molecular level. This …
(PTMs) and how they affect DNA-templated processes at the molecular level. This …
Establishment of H3K9-methylated heterochromatin and its functions in tissue differentiation and maintenance
Heterochromatin is characterized by dimethylated or trimethylated histone H3 Lys9
(H3K9me2 or H3K9me3, respectively) and is found at transposable elements, satellite …
(H3K9me2 or H3K9me3, respectively) and is found at transposable elements, satellite …
Molecular mechanisms of transgenerational epigenetic inheritance
MH Fitz-James, G Cavalli - Nature Reviews Genetics, 2022 - nature.com
Increasing evidence indicates that non-DNA sequence-based epigenetic information can be
inherited across several generations in organisms ranging from yeast to plants to humans …
inherited across several generations in organisms ranging from yeast to plants to humans …
Symmetric inheritance of parental histones governs epigenome maintenance and embryonic stem cell identity
Modified parental histones are segregated symmetrically to daughter DNA strands during
replication and can be inherited through mitosis. How this may sustain the epigenome and …
replication and can be inherited through mitosis. How this may sustain the epigenome and …
Advances in epigenetics link genetics to the environment and disease
Epigenetic research has accelerated rapidly in the twenty-first century, generating justified
excitement and hope, but also a degree of hype. Here we review how the field has evolved …
excitement and hope, but also a degree of hype. Here we review how the field has evolved …
METTL3 regulates heterochromatin in mouse embryonic stem cells
Abstract METTL3 (methyltransferase-like 3) mediates the N 6-methyladenosine (m6A)
methylation of mRNA, which affects the stability of mRNA and its translation into protein …
methylation of mRNA, which affects the stability of mRNA and its translation into protein …
Diverse silent chromatin states modulate genome compartmentalization and loop extrusion barriers
The relationships between chromosomal compartmentalization, chromatin state and function
are poorly understood. Here by profiling long-range contact frequencies in HCT116 colon …
are poorly understood. Here by profiling long-range contact frequencies in HCT116 colon …
HP1 reshapes nucleosome core to promote phase separation of heterochromatin
Heterochromatin affects genome function at many levels. It enables heritable gene
repression, maintains chromosome integrity and provides mechanical rigidity to the …
repression, maintains chromosome integrity and provides mechanical rigidity to the …
The ageing epigenome and its rejuvenation
Ageing is characterized by the functional decline of tissues and organs and the increased
risk of ageing-associated disorders. Several 'rejuvenating'interventions have been proposed …
risk of ageing-associated disorders. Several 'rejuvenating'interventions have been proposed …
Oncolytic viruses engineered to enforce cholesterol efflux restore tumor-associated macrophage phagocytosis and anti-tumor immunity in glioblastoma
S Wang, W Yan, L Kong, S Zuo, J Wu, C Zhu… - Nature …, 2023 - nature.com
The codependency of cholesterol metabolism sustains the malignant progression of
glioblastoma (GBM) and effective therapeutics remain scarce. In orthotopic GBM models in …
glioblastoma (GBM) and effective therapeutics remain scarce. In orthotopic GBM models in …