Cardiac electrophysiology is a complex system established by a plethora of inward and
outward ion currents in cardiomyocytes generating and conducting electrical signals in the …

The X‐linked inherited neuromuscular disorder Duchenne muscular dystrophy is
characterised by primary abnormalities in the membrane cytoskeletal component dystrophin …

Duchenne muscular dystrophy (DMD) is a fatal X-linked disease caused by mutations in the
DMD gene, leading to complete absence of dystrophin and progressive degeneration of …

Mammalian artificial chromosomes have enabled the introduction of extremely large
amounts of genetic information into animal cells in an autonomously replicating …

The 263rd ENMC International Workshop was convened in Amsterdam 13th-15th May 2022.
This was a hybrid meeting (participants took part either face to face or virtual via an on-line …

Over the past three decades, cell therapy development has fallen short of expectations, with
many cellular sources demonstrating a'Janus effect'and raising safety concerns …

Human DUX4 and its mouse ortholog Dux are normally expressed in the early embryo—the
4-cell or 2-cell cleavage stage embryo, respectively—and activate a portion of the first wave …

The 2-month-survival of a terminally ill patient who received a genetically modified pig heart
has demonstrated that cardiac xenotransplantation could provide a therapeutic option for …

Muscular dystrophy due to dystrophin deficiency in humans is phenotypically divided into a
severe Duchenne and milder Becker type. Dystrophin deficiency has also been described in …

Duchenne muscular dystrophy (DMD) is the most frequent genetic myopathy in childhood
and leads to progressive muscle atrophy, weakness, and premature death. So far, there is …