Organelles compartmentalize eukaryotic cells, enhancing their ability to respond to
environmental and developmental changes. One way in which organelles communicate and …

Autophagy is a highly conserved catabolic process induced under various conditions of
cellular stress, which prevents cell damage and promotes survival in the event of energy or …

The field of autophagy research has developed rapidly since the first description of the
process in the 1960s and the identification of autophagy genes in the 1990s. Autophagy is …

Close proximities between organelles have been described for decades. However, only
recently a specific field dealing with organelle communication at membrane contact sites …

Autophagy is a lysosome-dependent cellular degradation program that responds to a variety
of environmental and cellular stresses. It is an evolutionarily well-conserved and essential …

Autophagy, also known as macroautophagy, is a tightly regulated process involved in the
stress responses, such as starvation. It is a vacuolar, lysosomal pathway for the degradation …

Autophagosome biogenesis is a dynamic membrane event, which is executed by the
sequential function of autophagy-related (ATG) proteins. Upon autophagy induction, a cup …

The multispanning membrane protein ATG9A is a scramblase that flips phospholipids
between the two membrane leaflets, thus contributing to the expansion of the phagophore …

Cells have developed elaborate quality-control mechanisms for proteins and organelles to
maintain cellular homeostasis. Such quality-control mechanisms are maintained by …

Macroautophagy is a cellular quality-control process that degrades proteins, protein
aggregates and damaged organelles. Autophagy plays a fundamental role in cancer where …