The crystalline lens is a transparent and refractive biconvex structure formed by lens
epithelial cells (LECs) and lens fibers. Lens opacity, also known as cataracts, is the leading …

Eye formation is the result of coordinated induction and differentiation processes during
embryogenesis. Disruption of any one of these events has the potential to cause ocular …

Abstract ETS variant 4 (ETV4), together with ETV1 and ETV5, constitute the PEA3 subfamily
of ETS transcription factors, which are implicated in the progression of many cancers …

Mutations in the transcription factor genes FOXE3, HSF4, MAF, and PITX3 cause congenital
lens defects including cataracts that may be accompanied by defects in other components of …

Heat shock proteins (HSPs) are highly conserved molecular chaperones with diverse
cellular activities, including protein folding, assembly or disassembly of protein complexes …

Disorders of the anterior segment of the eye encompass a variety of clinical presentations
including aniridia, Axenfeld and Rieger anomalies, primary congenital glaucoma, Peters …

Pediatric cataract represents an important cause of pediatric visual impairment. While both
genetic and environmental causes for pediatric cataract are known, a large proportion …

Anterior segment dysgenesis is a severe developmental eye disorder that leads to blindness
in children. The exact mechanisms underlying this condition remain elusive. Recently, an …

Wilson disease (WD) is caused by inactivation of the copper transporter Atp7b and copper
overload in tissues. Mice with Atp7b deleted either globally (systemic inactivation) or only in …

Heritable Thoracic Aortic Disease Overview - Abstract - Europe PMC Sign in | Create an
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