Inflammation and oxidative stress are common and co-substantial pathological processes
accompanying, promoting, and even initiating numerous cancers. The canonical WNT/β …

The angiopoietin‐like 4 (ANGPTL4) protein belongs to a superfamily of secreted proteins
structurally related to factors modulating angiogenesis known as angiopoietins. At first …

Vascular endothelial growth factor (VEGF) is one of the most important inducers of
angiogenesis, therefore blocking angiogenesis has led to great promise in the treatment of …

Background Heterogeneity in bladder cancer results in variable clinical outcomes, posing
challenges for clinical management of this malignancy. Recent studies suggest both tumor …

The prevalence of obesity and metabolic diseases (such as type 2 diabetes mellitus,
dyslipidaemia, and cardiovascular diseases) has increased in the last decade, in both …

Obesity is a recognized risk factor for breast cancer development and poorer response to
therapy. Two major fat tissue-derived adipokines, leptin and adiponectin have been …

Epidemiological studies have reported that humans have detectable levels of not only
bisphenol A (BPA), but also its halogenated derivatives tetrabromobisphenol A (TBBPA) and …

More than one million new cases of breast cancer are diagnosed worldwide each year and
more than 400,000 deaths are caused by the disease. The origin of this pathology is …

Abstract Background Thiazolidinediones (TZDs), peroxisome proliferator-activated receptor-
γ (PPAR-γ) agonists, exhibit anti-inflammatory and antioxidant properties and inhibit …

The PPAR nuclear receptor family has acquired great relevance in the last decade, which is
formed by three different isoforms (PPARα, PPARβ/δ, and PPAR ϒ). Those nuclear …