Osteoarthritis (OA) is a chronic degenerative joint disorder that leads to disability and affects
more than 500 million population worldwide. OA was believed to be caused by the wearing …

Runx2 is a transcription factor that is essential for osteoblast differentiation and chondrocyte
maturation. Ihh, expressed in prehypertrophic and hypertrophic chondrocytes, is required for …

According to current dogma, chondrocytes and osteoblasts are considered independent
lineages derived from a common osteochondroprogenitor. In endochondral bone formation …

Runt-related transcription factor 2 (RUNX2) is a transcription factor closely associated with
the osteoblast phenotype. While frequently referred to, the complexity of its regulation and its …

The transcription factor Sox9 is necessary for early chondrogenesis, but its subsequent roles
in the cartilage growth plate, a highly specialized structure that drives skeletal growth and …

Temporomandibular joint (TMJ) osteoarthritis is a common chronic degenerative disease of
the TMJ. In order to explore its aetiology and pathological mechanism, many animal models …

Runx2 is the most upstream transcription factor essential for osteoblast differentiation. It
regulates the expression of Sp7, the protein of which is a crucial transcription factor for …

A milestone in the evolutionary emergence of vertebrates was the invention of cartilage, a
tissue that has key roles in modeling, protecting and complementing the bony skeleton …

The transcriptional regulator Runx2 (runt-related transcription factor 2) has essential but
distinct roles in osteoblasts and chondrocytes in skeletal development. However, Runx2 …

Hippo signaling controls organ size and tissue regeneration in many organs, but its roles in
chondrocyte differentiation and bone repair remain elusive. Here, we demonstrate that …