Osteoarthritis: pathogenic signaling pathways and therapeutic targets
Osteoarthritis (OA) is a chronic degenerative joint disorder that leads to disability and affects
more than 500 million population worldwide. OA was believed to be caused by the wearing …
more than 500 million population worldwide. OA was believed to be caused by the wearing …
Runx2, an inducer of osteoblast and chondrocyte differentiation
T Komori - Histochemistry and cell biology, 2018 - Springer
Runx2 is a transcription factor that is essential for osteoblast differentiation and chondrocyte
maturation. Ihh, expressed in prehypertrophic and hypertrophic chondrocytes, is required for …
maturation. Ihh, expressed in prehypertrophic and hypertrophic chondrocytes, is required for …
Hypertrophic chondrocytes can become osteoblasts and osteocytes in endochondral bone formation
L Yang, KY Tsang, HC Tang… - Proceedings of the …, 2014 - National Acad Sciences
According to current dogma, chondrocytes and osteoblasts are considered independent
lineages derived from a common osteochondroprogenitor. In endochondral bone formation …
lineages derived from a common osteochondroprogenitor. In endochondral bone formation …
[PDF][PDF] Role and regulation of RUNX2 in osteogenesis
Runt-related transcription factor 2 (RUNX2) is a transcription factor closely associated with
the osteoblast phenotype. While frequently referred to, the complexity of its regulation and its …
the osteoblast phenotype. While frequently referred to, the complexity of its regulation and its …
[HTML][HTML] Sox9 directs hypertrophic maturation and blocks osteoblast differentiation of growth plate chondrocytes
P Dy, W Wang, P Bhattaram, Q Wang, L Wang… - Developmental cell, 2012 - cell.com
The transcription factor Sox9 is necessary for early chondrogenesis, but its subsequent roles
in the cartilage growth plate, a highly specialized structure that drives skeletal growth and …
in the cartilage growth plate, a highly specialized structure that drives skeletal growth and …
Pathological mechanism of chondrocytes and the surrounding environment during osteoarthritis of temporomandibular joint
B Li, G Guan, L Mei, K Jiao, H Li - Journal of cellular and …, 2021 - Wiley Online Library
Temporomandibular joint (TMJ) osteoarthritis is a common chronic degenerative disease of
the TMJ. In order to explore its aetiology and pathological mechanism, many animal models …
the TMJ. In order to explore its aetiology and pathological mechanism, many animal models …
Roles of Runx2 in skeletal development
T Komori - RUNX Proteins in development and cancer, 2017 - Springer
Runx2 is the most upstream transcription factor essential for osteoblast differentiation. It
regulates the expression of Sp7, the protein of which is a crucial transcription factor for …
regulates the expression of Sp7, the protein of which is a crucial transcription factor for …
Transcriptional control of chondrocyte specification and differentiation
CF Liu, WE Samsa, G Zhou, V Lefebvre - Seminars in cell & developmental …, 2017 - Elsevier
A milestone in the evolutionary emergence of vertebrates was the invention of cartilage, a
tissue that has key roles in modeling, protecting and complementing the bony skeleton …
tissue that has key roles in modeling, protecting and complementing the bony skeleton …
Runx2 regulates chromatin accessibility to direct the osteoblast program at neonatal stages
The transcriptional regulator Runx2 (runt-related transcription factor 2) has essential but
distinct roles in osteoblasts and chondrocytes in skeletal development. However, Runx2 …
distinct roles in osteoblasts and chondrocytes in skeletal development. However, Runx2 …
Yap1 regulates multiple steps of chondrocyte differentiation during skeletal development and bone repair
Hippo signaling controls organ size and tissue regeneration in many organs, but its roles in
chondrocyte differentiation and bone repair remain elusive. Here, we demonstrate that …
chondrocyte differentiation and bone repair remain elusive. Here, we demonstrate that …