Pathogenetic mechanisms and treatment targets in cerebral malaria
Malaria, the most prevalent mosquito-borne infectious disease worldwide, has accompanied
humanity for millennia and remains an important public health issue despite advances in its …
humanity for millennia and remains an important public health issue despite advances in its …
Normalizing the environment recapitulates adult human immune traits in laboratory mice
Our current understanding of immunology was largely defined in laboratory mice, partly
because they are inbred and genetically homogeneous, can be genetically manipulated …
because they are inbred and genetically homogeneous, can be genetically manipulated …
The ins and outs of cerebral malaria pathogenesis: immunopathology, extracellular vesicles, immunometabolism, and trained immunity
Complications from malaria parasite infections still cost the lives of close to half a million
people every year. The most severe is cerebral malaria (CM). Employing murine models of …
people every year. The most severe is cerebral malaria (CM). Employing murine models of …
CD8+ T Cells Induce Fatal Brainstem Pathology during Cerebral Malaria via Luminal Antigen-Specific Engagement of Brain Vasculature
Cerebral malaria (CM) is a severe complication of Plasmodium falciparum infection that
results in thousands of deaths each year, mostly in African children. The in vivo mechanisms …
results in thousands of deaths each year, mostly in African children. The in vivo mechanisms …
Daily rhythms of TNFα expression and food intake regulate synchrony of Plasmodium stages with the host circadian cycle
IC Hirako, PA Assis, NS Hojo-Souza, G Reed… - Cell host & …, 2018 - cell.com
The Plasmodium cell cycle, wherein millions of parasites differentiate and proliferate, occurs
in synchrony with the vertebrate host's circadian cycle. The underlying mechanisms are …
in synchrony with the vertebrate host's circadian cycle. The underlying mechanisms are …
Targeting glutamine metabolism rescues mice from late-stage cerebral malaria
The most deadly complication of Plasmodium falciparum infection is cerebral malaria (CM)
with a case fatality rate of 15–25% in African children despite effective antimalarial …
with a case fatality rate of 15–25% in African children despite effective antimalarial …
FDA-approved kinase inhibitors in preclinical and clinical trials for neurological disorders
A Lui, J Vanleuven, D Perekopskiy, D Liu, D Xu… - Pharmaceuticals, 2022 - mdpi.com
Cancers and neurological disorders are two major types of diseases. We previously
developed a new concept termed “Aberrant Cell Cycle Diseases”(ACCD), revealing that …
developed a new concept termed “Aberrant Cell Cycle Diseases”(ACCD), revealing that …
miR-155 modifies inflammation, endothelial activation and blood-brain barrier dysfunction in cerebral malaria
Abstract miR-155 has been shown to participate in host response to infection and
neuroinflammation via negative regulation of blood-brain barrier (BBB) integrity and T cell …
neuroinflammation via negative regulation of blood-brain barrier (BBB) integrity and T cell …
Enhanced translation expands the endo-lysosome size and promotes antigen presentation during phagocyte activation
VEB Hipolito, JA Diaz, KV Tandoc, C Oertlin… - PLoS …, 2019 - journals.plos.org
The mechanisms that govern organelle adaptation and remodelling remain poorly defined.
The endo-lysosomal system degrades cargo from various routes, including endocytosis …
The endo-lysosomal system degrades cargo from various routes, including endocytosis …
The host mTOR pathway and parasitic diseases pathogenesis
S Rashidi, R Mansouri, M Ali-Hassanzadeh… - Parasitology …, 2021 - Springer
The mechanistic (or mammalian) target of rapamycin (mTOR) is considered as a critical
regulatory enzyme involved in essential signaling pathways affecting cell growth, cell …
regulatory enzyme involved in essential signaling pathways affecting cell growth, cell …