The mechanisms through which general anaesthetics, an extremely diverse group of drugs,
cause reversible loss of consciousness have been a long-standing mystery. Gradually, a …

In designing the anaesthetic plan for patients undergoing surgery, the choice of anaesthetic
agent may often appear irrelevant and the best results obtained by the use of a technique or …

Background Neuroapoptosis is induced by the administration of anesthetic agents to the
young. As alpha2 adrenoceptor signaling plays a trophic role during development and is …

Which of the three α2-adrenoceptor subtypes of α2A, α2B, or α2C mediates the
neuroprotective effect of dexmedetomidine was examined in cell culture as well as in an in …

Nitrous oxide, xenon, and cyclopropane are anesthetic gases that have a distinct
pharmacological profile. Whereas the molecular basis for their anesthetic actions remains …

Perinatal asphyxia can result in neuronal injury with long‐term neurological and behavioral
consequences. Although hypothermia may provide some modest benefit, the intervention …

Background Inhibition of N-methyl-D-aspartate (NMDA) receptors by anesthetic gases and
vapors may play an important role in anesthesia and neuroprotection. However, the site of …

Background Anesthetics, including isoflurane and nitrous oxide, an antagonist of the N-
methyl-D-aspartate subtype of the glutamate receptor, have been demonstrated to induce …

Importance Evidence from preclinical models indicates that xenon gas can prevent the
development of cerebral damage after acute global hypoxic-ischemic brain injury but, thus …

Growing and consistent preclinical evidence, combined with early clinical epidemiological
observations, suggest potentially neurotoxic effects of commonly used anesthetic agents in …