Autoimmune diseases are characterized by aberrant immune responses against healthy
cells and tissues. However, the exact mechanisms underlying the development of these …

In the gut, where billions of non-self-antigens from the food and the microbiota are present,
the immune response must be tightly regulated to ensure both host protection against …

Background Transmaternal exposure to tobacco, microbes, nutrients, and other
environmental factors shapes the fetal immune system through epigenetic processes. The …

The T cell signaling protein Themis1 is essential for the positive and negative selection of
thymocytes in the thymus. Although the developmental defect that results from the loss of …

The guanine nucleotide exchange factor (GEF) VAV1, a previously 'undruggable'protein
integral to T/B lymphocyte antigen–receptor signaling, promotes actin polymerization …

The activity of T cells is finely controlled by a set of negative regulators of T-cell antigen
receptor (TCR)-mediated signaling. However, how those negative regulators are themselves …

Regulatory T cells (Treg) represent a minor subpopulation of T lymphocytes that is crucial for
the maintenance of immune homeostasis. Here, we present a large-scale quantitative mass …

The susceptibility to autoimmune diseases is conditioned by the association of modest
genetic alterations which altogether weaken self-tolerance. The mechanism whereby these …

Regulatory T cells (Tregs) are a specialized subgroup of T-cell lymphocytes that is crucial for
maintaining immune homeostasis and preventing excessive immune responses. Depending …

Both skin-derived precursors (SKPs) and dermal mesenchymal stem cells (dMSCs) are
promising candidates for cellular therapy and regenerative medicine. To date the …