Furan-containing polymeric Materials: Harnessing the Diels-Alder chemistry for biomedical applications

TN Gevrek, A Sanyal - European Polymer Journal, 2021 - Elsevier
Polymeric materials that can be readily modified with (bio) molecules of interest to render
them suitable for intended applications are in demand for use in various areas of biomedical …

Diels–Alder click-cross-linked hydrogels with increased reactivity enable 3D cell encapsulation

LJ Smith, SM Taimoory, RY Tam, AEG Baker… - …, 2018 - ACS Publications
Engineered hydrogels have been extensively used to direct cell function in 3D cell culture
models, which are more representative of the native cellular microenvironment than …

Click-functionalized hydrogel design for mechanobiology investigations

E Hui, JL Sumey, SR Caliari - Molecular systems design & …, 2021 - pubs.rsc.org
The advancement of click-functionalized hydrogels in recent years has coincided with rapid
growth in the fields of mechanobiology, tissue engineering, and regenerative medicine …

Rapid diels–alder cross-linking of cell encapsulating hydrogels

CM Madl, SC Heilshorn - Chemistry of Materials, 2019 - ACS Publications
Recent efforts in the design of hydrogel biomaterials have focused on better mimicking the
native cellular microenvironment to direct cell fate. To simultaneously control multiple …

Hydrogen-bonding-driven multifunctional polymer hydrogel networks based on tannic acid

Y Gao, X Peng, Q Wu, D Yang, W Wang… - ACS Applied Polymer …, 2022 - ACS Publications
A hydrogel network based on noncovalent intermolecular interactions via mixing of poly
(methyl vinyl ether-alt-maleic anhydride)(PMVEMA), poly (vinyl alcohol)(PVA), and tannic …

Chemical cross-linking methods for cell encapsulation in hydrogels

C Echalier, L Valot, J Martinez, A Mehdi… - Materials Today …, 2019 - Elsevier
Cell-encapsulating hydrogels are of tremendous interest in regenerative medicine. Tissue
engineering relies on biomaterials able to act as artificial extracellular matrices to guide cells …

Synthesis and characterization of a biocompatible chitosan–based hydrogel cross–linked via 'click'chemistry for controlled drug release

O Guaresti, C García–Astrain, T Palomares… - International journal of …, 2017 - Elsevier
A chemically cross–linked chitosan–based hydrogel was successfully synthesized through
Diels–Alder (DA) reaction and characterized. The final product was obtained after different …

Synthesis of stimuli–responsive chitosan–based hydrogels by Diels–Alder cross–linkingclick reaction as potential carriers for drug administration

O Guaresti, C García–Astrain, RH Aguirresarobe… - Carbohydrate …, 2018 - Elsevier
Stimuli–responsive chitosan–based hydrogels for biomedical applications using the Diels–
Alder reaction were prepared. Furan modified chitosan (Cs–Fu) was cross–linked with …

Design and Synthesis of Chitosan—Gelatin Hybrid Hydrogels for 3D Printable in vitro Models

S Magli, GB Rossi, G Risi, S Bertini, C Cosentino… - Frontiers in …, 2020 - frontiersin.org
The development of 3D printable hydrogels based on the crosslinking between chitosan and
gelatin is proposed. Chitosan and gelatin were both functionalized with methyl furan groups …

Ultrasound-responsive hydrogels for on-demand protein release

JH Arrizabalaga, M Smallcomb… - ACS applied bio …, 2022 - ACS Publications
The development of tunable, ultrasound-responsive hydrogels that can deliver protein
payload on-demand when exposed to focused ultrasound is described in this study …