Diffuse glioma heterogeneity and its therapeutic implications
JG Nicholson, HA Fine - Cancer discovery, 2021 - AACR
Diffuse gliomas represent a heterogeneous group of universally lethal brain tumors
characterized by minimally effective genotype-targeted therapies. Recent advances have …
characterized by minimally effective genotype-targeted therapies. Recent advances have …
Mutant isocitrate dehydrogenase inhibitors as targeted cancer therapeutics
The identification of heterozygous neomorphic isocitrate dehydrogenase (IDH) mutations
across multiple cancer types including both solid and hematologic malignancies has …
across multiple cancer types including both solid and hematologic malignancies has …
Suppression of antitumor T cell immunity by the oncometabolite (R)-2-hydroxyglutarate
Abstract The oncometabolite (R)-2-hydroxyglutarate (R-2-HG) produced by isocitrate
dehydrogenase (IDH) mutations promotes gliomagenesis via DNA and histone methylation …
dehydrogenase (IDH) mutations promotes gliomagenesis via DNA and histone methylation …
[HTML][HTML] Biological role and therapeutic potential of IDH mutations in cancer
Hotspot mutations in isocitrate dehydrogenase 1 (IDH1) and isocitrate dehydrogenase 2
(IDH2) occur in a variety of myeloid malignancies and solid tumors. Mutant IDH proteins …
(IDH2) occur in a variety of myeloid malignancies and solid tumors. Mutant IDH proteins …
Signaling pathways in brain tumors and therapeutic interventions
S Li, C Wang, J Chen, Y Lan, W Zhang… - … and Targeted Therapy, 2023 - nature.com
Brain tumors, although rare, contribute to distinct mortality and morbidity at all ages.
Although there are few therapeutic options for brain tumors, enhanced biological …
Although there are few therapeutic options for brain tumors, enhanced biological …
Glioma: experimental models and reality
K Lenting, R Verhaak, M Ter Laan, P Wesseling… - Acta …, 2017 - Springer
In theory, in vitro and in vivo models for human gliomas have great potential to not only
enhance our understanding of glioma biology, but also to facilitate the development of novel …
enhance our understanding of glioma biology, but also to facilitate the development of novel …
The roles of 2-hydroxyglutarate
X Du, H Hu - Frontiers in Cell and Developmental Biology, 2021 - frontiersin.org
2-Hydroxyglutarate (2-HG) is structurally similar to α-ketoglutarate (α-KG), which is an
intermediate product of the tricarboxylic acid (TCA) cycle; it can be generated by reducing …
intermediate product of the tricarboxylic acid (TCA) cycle; it can be generated by reducing …
De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma
Mutations affecting isocitrate dehydrogenase (IDH) enzymes are prevalent in glioma,
leukemia, and other cancers. Although mutant IDH inhibitors are effective against leukemia …
leukemia, and other cancers. Although mutant IDH inhibitors are effective against leukemia …
Evolution of experimental models in the study of glioblastoma: toward finding efficient treatments
R Gómez-Oliva, S Domínguez-García… - Frontiers in …, 2021 - frontiersin.org
Glioblastoma (GBM) is the most common form of brain tumor characterized by its resistance
to conventional therapies, including temozolomide, the most widely used chemotherapeutic …
to conventional therapies, including temozolomide, the most widely used chemotherapeutic …
Glioblastoma stem cells: lessons from the tumor hierarchy in a lethal cancer
Glioblastoma ranks among the most lethal of all human cancers. Glioblastomas display
striking cellular heterogeneity, with stem-like glioblastoma stem cells (GSCs) at the apex …
striking cellular heterogeneity, with stem-like glioblastoma stem cells (GSCs) at the apex …