Twenty years of transcriptomics, 17alpha-ethinylestradiol, and fish

CJ Martyniuk, A Feswick, KR Munkittrick… - General and …, 2020 - Elsevier
In aquatic toxicology, perhaps no pharmaceutical has been investigated more intensely than
17alpha-ethinylestradiol (EE2), the active ingredient of the birth control pill. At the turn of the …

Uptake and tissue distribution of pharmaceuticals and personal care products in wild fish from treated-wastewater-impacted streams

R Tanoue, K Nomiyama, H Nakamura… - … science & technology, 2015 - ACS Publications
A fish plasma model (FPM) has been proposed as a screening technique to prioritize
potential hazardous pharmaceuticals to wild fish. However, this approach does not account …

[PDF][PDF] Active pharmaceutical ingredients and aquatic organisms

CG Daughton, BW Brooks - Environmental contaminants in …, 2011 - api.taylorfrancis.com
The presence of active pharmaceuticals ingredients (APIs) in aquatic systems has led in
recent years to a burgeoning literature examining environmental occurrence, fate, effects …

RNA-Seq analysis of transcriptome responses in Atlantic cod (Gadus morhua) precision-cut liver slices exposed to benzo [a] pyrene and 17α-ethynylestradiol

F Yadetie, X Zhang, EM Hanna, L Aranguren-Abadía… - Aquatic toxicology, 2018 - Elsevier
Polycyclic aromatic hydrocarbons such as benzo [a] pyrene (BaP) that activate the aryl
hydrocarbon receptor (Ahr) pathway, and endocrine disruptors acting through the estrogen …

Uptake of human pharmaceuticals in bull sharks (Carcharhinus leucas) inhabiting a wastewater-impacted river

J Gelsleichter, NJ Szabo - Science of the total environment, 2013 - Elsevier
The presence of human pharmaceuticals in sewage-impacted ecosystems is a growing
concern that poses health risks to aquatic wildlife. Despite this, few studies have …

Gonadal transcriptome responses and physiological consequences of exposure to oestrogen in breeding zebrafish (Danio rerio)

EM Santos, GC Paull, KJW Van Look, VL Workman… - Aquatic toxicology, 2007 - Elsevier
Environmental oestrogens are widespread in the aquatic environment and cause alterations
in sexual development and function in vertebrates. The molecular pathways underpinning …

Promise and progress in environmental genomics: a status report on the applications of gene expression‐based microarray studies in ecologically relevant fish …

SE Hook - Journal of fish biology, 2010 - Wiley Online Library
The advent of any new technology is typically met with great excitement. So it was a few
years ago, when the combination of advances in sequencing technology and the …

Dietary exposure of 17-alpha ethinylestradiol modulates physiological endpoints and gene signaling pathways in female largemouth bass (Micropterus salmoides)

RC Colli-Dula, CJ Martyniuk, KJ Kroll, MS Prucha… - Aquatic toxicology, 2014 - Elsevier
Abstract 17Alpha-ethinylestradiol (EE2), used for birth control in humans, is a potent
estrogen that is found in wastewater at low concentrations (ng/l). EE2 has the ability to …

17α-Ethinylestradiol (EE2) effect on global gene expression in primary rainbow trout (Oncorhynchus mykiss) hepatocytes

MT Hultman, Y Song, KE Tollefsen - Aquatic Toxicology, 2015 - Elsevier
The potential impact of endocrine disrupting chemicals (EDCs) in the aquatic environment
has driven the development of screening assays to evaluate the estrogenic properties of …

Low concentrations, potential ecological consequences: synthetic estrogens alter life-history and demographic structures of aquatic invertebrates

MS Souza, P Hallgren, E Balseiro, LA Hansson - Environmental Pollution, 2013 - Elsevier
Contraceptive drugs are nowadays found in aquatic environments around the globe.
Particularly, 17α-ethinylestradiol (EE2) may act even at low concentrations, such as those …