Microfluidics for neuronal cell and circuit engineering
The widespread adoption of microfluidic devices among the neuroscience and neurobiology
communities has enabled addressing a broad range of questions at the molecular, cellular …
communities has enabled addressing a broad range of questions at the molecular, cellular …
[HTML][HTML] Neural Stem Cells and Methods for Their Generation From Induced Pluripotent Stem Cells in vitro
AA Galiakberova, EB Dashinimaev - Frontiers in cell and …, 2020 - frontiersin.org
Neural stem cells (NSCs) provide promising approaches for investigating embryonic
neurogenesis, modeling of the pathogenesis of diseases of the central nervous system, and …
neurogenesis, modeling of the pathogenesis of diseases of the central nervous system, and …
[HTML][HTML] Cholesterol and matrisome pathways dysregulated in astrocytes and microglia
The impact of apolipoprotein E ε4 (APOE4), the strongest genetic risk factor for Alzheimer's
disease (AD), on human brain cellular function remains unclear. Here, we investigated the …
disease (AD), on human brain cellular function remains unclear. Here, we investigated the …
CRISPRi screens in human iPSC-derived astrocytes elucidate regulators of distinct inflammatory reactive states
Astrocytes become reactive in response to insults to the central nervous system by adopting
context-specific cellular signatures and outputs, but a systematic understanding of the …
context-specific cellular signatures and outputs, but a systematic understanding of the …
Synergistic effects of common schizophrenia risk variants
The mechanisms by which common risk variants of small effect interact to contribute to
complex genetic disorders are unclear. Here, we apply a genetic approach, using isogenic …
complex genetic disorders are unclear. Here, we apply a genetic approach, using isogenic …
[HTML][HTML] MicroRNA-195 rescues ApoE4-induced cognitive deficits and lysosomal defects in Alzheimer's disease pathogenesis
J Cao, M Huang, L Guo, L Zhu, J Hou, L Zhang… - Molecular …, 2021 - nature.com
Our recent findings link the apolipoprotein E4 (ApoE4)-specific changes in brain
phosphoinositol biphosphate (PIP2) homeostasis to the susceptibility of developing …
phosphoinositol biphosphate (PIP2) homeostasis to the susceptibility of developing …
[HTML][HTML] Circadian clock regulator Bmal1 gates axon regeneration via Tet3 epigenetics in mouse sensory neurons
D Halawani, Y Wang, A Ramakrishnan, M Estill… - Nature …, 2023 - nature.com
Axon regeneration of dorsal root ganglia (DRG) neurons after peripheral axotomy involves
reconfiguration of gene regulatory circuits to establish regenerative gene programs …
reconfiguration of gene regulatory circuits to establish regenerative gene programs …
Tumorigenicity risk of iPSCs in vivo: nip it in the bud
C Zhong, M Liu, X Pan, H Zhu - Precision Clinical Medicine, 2022 - academic.oup.com
Abstract In 2006, Takahashi and Yamanaka first created induced pluripotent stem cells from
mouse fibroblasts via the retroviral introduction of genes encoding the transcription factors …
mouse fibroblasts via the retroviral introduction of genes encoding the transcription factors …
[HTML][HTML] Human iPSC-derived astrocytes transplanted into the mouse brain undergo morphological changes in response to amyloid-β plaques
P Preman, J Tcw, S Calafate, A Snellinx… - Molecular …, 2021 - Springer
Background Increasing evidence for a direct contribution of astrocytes to neuroinflammatory
and neurodegenerative processes causing Alzheimer's disease comes from molecular and …
and neurodegenerative processes causing Alzheimer's disease comes from molecular and …
Cholesterol and matrisome pathways dysregulated in human APOE ε4 glia
Apolipoprotein E (APOE) ε4 is the strongest genetic risk factor for Alzheimer's disease (AD).
Although its association with AD is well-established, the impact of APOE ε4 on human brain …
Although its association with AD is well-established, the impact of APOE ε4 on human brain …