Abstract The statin drugs ('statins') potently inhibit hydroxymethylglutaryl-coenzyme A (HMG-
CoA) reductase by competitively blocking the active site of the enzyme. Statins decrease de …

Approximately 25% of US adults are estimated to have hypertriglyceridemia (triglyceride
[TG] level≥ 150 mg/dL [≥ 1.7 mmol/L]). Elevated TG levels are associated with increased …

Abstract Hypertriglyceridemia (triglycerides> 150 mg/dL) affects~ 25% of the United States
(US) population and is associated with increased cardiovascular risk. Severe …

The major public health concern worldwide is coronary heart disease, with dyslipidemia as a
major risk factor. Statin drugs are recommended by several guidelines for both primary and …

Aims (i) To examine the incidence of new onset treated diabetes in patients treated with
different types of statins and (ii) the relationship between the duration and dose of statins …

Background Cholesterol management drugs known as statins are widely used and often
well tolerated; however, a variety of muscle-related side effects can arise. These adverse …

Introduction: Statin monotherapy is generally well tolerated, with a low frequency of adverse
events. The most important adverse effects associated with statins are myopathy and an …

Chronic kidney disease has a significant worldwide prevalence affecting 7.2% of the global
adult population with the number dramatically increasing in the elderly. Although the causes …

Rosuvastatin is a fully synthetic statin wich acts by interfering with the endogenous synthesis
of cholesterol through competitively inhibiting the 3-hydroxy-3-methylglutaryl coenzyme A …

Background One of the most serious secondary manifestations of Cardiovascular Disease
(CVD) is coronary atherosclerosis. This study aimed to evaluate whether aged garlic extract …