The hematopoietic cell kinase (HCK) is a member of the SRC family of cytoplasmic tyrosine
kinases (SFKs), and is expressed in cells of the myeloid and B-lymphocyte cell lineages …

Members of the Src family of kinases (SFKs) are non-receptor tyrosine kinases involved in
numerous signal transduction pathways. The catalytic, SH3 and SH2 domains are attached …

The Middle East respiratory syndrome-coronavirus (MERS-CoV), first identified in Saudi
Arabia, is an emerging zoonotic pathogen that causes severe acute respiratory illness in …

Macrophages are motile leukocytes, targeted by HIV-1, thought to play a critical role in host
dissemination of the virus. However, whether infection impacts their migration capacity …

Heterocyclic compounds play an important role in the field of pharmaceutical chemistry,
especially compounds containing hybrid bioactive moieties. So in continuation of our work …

The crosstalk between hematopoietic stem/progenitor cells (HSC), both normal and
leukemic, and their neighboring bone marrow (BM) microenvironment (niche) creates a …

New drug development for neoplasm treatment is nowadays based on molecular targets that
participate in the disease pathogenesis and tumor phenotype. Herein, we describe a new …

Myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) are characterized by
risk of relapses, poor survival, unwanted side effects and high toxicity with the current …

Abnormal activation of B-cell receptor (BCR) signaling plays a key role in the development
of lymphoid malignancies, and could be reverted by the simultaneous inhibition of Lyn, Fyn …

US10005734B2 - Pyridin-2(1H)-one quinolinone derivatives as mutant-isocitrate
dehydrogenase inhibitors - Google Patents US10005734B2 - Pyridin-2(1H)-one …