Copper homeostasis and cuproptosis in health and disease
L Chen, J Min, F Wang - Signal transduction and targeted therapy, 2022 - nature.com
As an essential micronutrient, copper is required for a wide range of physiological processes
in virtually all cell types. Because the accumulation of intracellular copper can induce …
in virtually all cell types. Because the accumulation of intracellular copper can induce …
Cuproptosis: Harnessing transition metal for cancer therapy
Transition metal elements, such as copper, play diverse and pivotal roles in oncology. They
act as constituents of metalloenzymes involved in cellular metabolism, function as signaling …
act as constituents of metalloenzymes involved in cellular metabolism, function as signaling …
[HTML][HTML] Copper metabolism as a unique vulnerability in cancer
The last 25 years have witnessed tremendous progress in identifying and characterizing
proteins that regulate the uptake, intracellular trafficking and export of copper. Although …
proteins that regulate the uptake, intracellular trafficking and export of copper. Although …
Intratumoral copper modulates PD-L1 expression and influences tumor immune evasion
Therapeutic checkpoint antibodies blocking programmed death receptor 1/programmed
death ligand 1 (PD-L1) signaling have radically improved clinical outcomes in cancer …
death ligand 1 (PD-L1) signaling have radically improved clinical outcomes in cancer …
The multifaceted roles of copper in cancer: A trace metal element with dysregulated metabolism, but also a target or a bullet for therapy
Simple Summary Copper is an essential element for human life. However, its redox activity
can be detrimental for the cell that developed highly coordinated pathways to chelate and …
can be detrimental for the cell that developed highly coordinated pathways to chelate and …
Advances in copper complexes as anticancer agents
Medicinal inorganic chemistry offers additional opportunities for the design of therapeutic
agents not accessible to organic compounds. 1− 3 The wide range of coordination numbers …
agents not accessible to organic compounds. 1− 3 The wide range of coordination numbers …
Recent advances in repurposing disulfiram and disulfiram derivatives as copper-dependent anticancer agents
Copper (Cu) plays a pivotal role in cancer progression by acting as a co-factor that regulates
the activity of many enzymes and structural proteins in cancer cells. Therefore, Cu-based …
the activity of many enzymes and structural proteins in cancer cells. Therefore, Cu-based …
Dissecting copper biology and cancer treatment:'Activating Cuproptosis or suppressing Cuproplasia'
Y Yang, M Li, G Chen, S Liu, H Guo, X Dong… - Coordination Chemistry …, 2023 - Elsevier
Copper, an essential micronutrient, controls multiple fundamental processes throughout all
forms of life, such as respiration, cell proliferation and neurotransmitter biosynthesis. High …
forms of life, such as respiration, cell proliferation and neurotransmitter biosynthesis. High …
Novel metals and metal complexes as platforms for cancer therapy
M Frezza, S Hindo, D Chen… - Current …, 2010 - ingentaconnect.com
Metals are essential cellular components selected by nature to function in several
indispensable biochemical processes for living organisms. Metals are endowed with unique …
indispensable biochemical processes for living organisms. Metals are endowed with unique …
Inflammation mobilizes copper metabolism to promote colon tumorigenesis via an IL-17-STEAP4-XIAP axis
Copper levels are known to be elevated in inflamed and malignant tissues. But the
mechanism underlying this selective enrichment has been elusive. In this study, we report a …
mechanism underlying this selective enrichment has been elusive. In this study, we report a …