Intramolecular hydrogen bonding: An opportunity for improved design in medicinal chemistry
Recent literature shows that intramolecular hydrogen bond (IMHB) formation can positively
impact upon the triad of permeability, solubility, and potency of drugs and candidates. IMHB …
impact upon the triad of permeability, solubility, and potency of drugs and candidates. IMHB …
The rise of PAMPA
A Avdeef - Expert opinion on drug metabolism & toxicology, 2005 - Taylor & Francis
The parallel artificial membrane permeability assay (PAMPA), as a passive-permeability
screen, is a possible low-cost alternative to cellular models for the earliest ADME primary …
screen, is a possible low-cost alternative to cellular models for the earliest ADME primary …
Conformational effects on the passive membrane permeability of synthetic macrocycles
AA Rzepiela, LA Viarengo-Baker… - Journal of medicinal …, 2022 - ACS Publications
Macrocyclic compounds (MCs) can have complex conformational properties that affect
pharmacologically important behaviors such as membrane permeability. We measured the …
pharmacologically important behaviors such as membrane permeability. We measured the …
Interfacial design and functionization on metal electrodes through self-assembled monolayers
D Chen, J Li - Surface Science Reports, 2006 - Elsevier
Self-assembled monolayers (SAMs) provide a convenient, flexible, and simple system with
which to tailor and functionalize the interfacial properties of metal electrodes. The SAMs on …
which to tailor and functionalize the interfacial properties of metal electrodes. The SAMs on …
A physiologically based pharmacokinetic model for pregnant women to predict the pharmacokinetics of drugs metabolized via several enzymatic pathways
Background Physiologically based pharmacokinetic modeling is considered a valuable tool
for predicting pharmacokinetic changes in pregnancy to subsequently guide in-vivo …
for predicting pharmacokinetic changes in pregnancy to subsequently guide in-vivo …
Transformation of biopharmaceutical classification system class I and III drugs into ionic liquids and lipophilic salts for enhanced developability using lipid formulations
HD Williams, L Ford, S Lim, S Han, J Baumann… - Journal of …, 2018 - Elsevier
Higher lipid solubility of lipophilic salt forms creates new product development opportunities
for high-dose liquid-filled capsules. The purpose of this study is to determine if lipophilic …
for high-dose liquid-filled capsules. The purpose of this study is to determine if lipophilic …
Amlodipine besylate
G Ananchenko, J Novakovic, J Lewis - Profiles of Drug Substances …, 2012 - Elsevier
A review on physical and chemical properties, methods of preparation and analysis, as well
as pharmacodynamics and pharmacokinetics of amlodipine besylate (3-ethyl 5-methyl …
as pharmacodynamics and pharmacokinetics of amlodipine besylate (3-ethyl 5-methyl …
[HTML][HTML] Interaction of PEGylated anti-hypertensive drugs, amlodipine, atenolol and lisinopril with lipid bilayer membrane: A molecular dynamics simulation study
A Yousefpour, H Modarress, F Goharpey… - … et Biophysica Acta (BBA …, 2015 - Elsevier
The interaction of PEGylated anti-hypertensive drugs, amlodipine, atenolol and lisinopril
with lipid bilayer membrane dimyristoylphosphatidylcholine (DMPC) has been studied in …
with lipid bilayer membrane dimyristoylphosphatidylcholine (DMPC) has been studied in …
Calculating Virtual log P in the Alkane/Water System (log PNalk) and Its Derived Parameters Δlog PNoct-alk and log DpHalk
Growing interest in the use of both the logarithm of the partition coefficient of the neutral
species in the alkane/water system (log P Nalk) and the difference between log P Noct (the …
species in the alkane/water system (log P Nalk) and the difference between log P Noct (the …
[HTML][HTML] Guiding dose adjustment of amlodipine after co-administration with ritonavir containing regimens using a physiologically-based pharmacokinetic …
D Mukherjee, J Zha, RM Menon, M Shebley - Journal of pharmacokinetics …, 2018 - Springer
Amlodipine, a commonly prescribed anti-hypertensive drug, shows increased systemic
exposure with cytochrome P450 (CYP) 3A inhibitors. Ritonavir (RTV) is a potent mechanism …
exposure with cytochrome P450 (CYP) 3A inhibitors. Ritonavir (RTV) is a potent mechanism …