Acute myocardial infarction is caused by a sudden coronary artery occlusion and leads to
ischemia in the corresponding myocardial territory which generally results in myocardial …

The potential for ischemic preconditioning to reduce infarct size was first recognized more
than 30 years ago [180]. Despite extension of the concept to ischemic postcondition‑ing …

Background Experimental and clinical evidence suggests that cyclosporine may attenuate
reperfusion injury and reduce myocardial infarct size. We aimed to test whether cyclosporine …

Background On-pump cardiac surgery provokes a predictable perioperative myocardial
ischaemia–reperfusion injury which is associated with poor clinical outcomes. We …

Ischaemic heart disease (IHD) remains the leading cause of death and disability in Europe
and worldwide. A major cause of morbidity and mortality in IHD patients is an acute ST …

Ischemic heart disease (IHD) remains the leading cause of death and disability worldwide.
For patients presenting with an acute myocardial infarction, the most effective treatment for …

Mitochondrial permeability transition, as the consequence of opening of a mitochondrial
permeability transition pore (mPTP), is a cellular catastrophe. Initiating bioenergetic collapse …

The mitochondrial permeability transition is a key event in cell death. Intense research efforts
have been focused on elucidating the molecular components of the mitochondrial …

The translation of cardioprotection from robust experimental evidence to beneficial clinical
outcome for patients suffering acute myocardial infarction or undergoing cardiovascular …

Coronary artery disease (CAD) is one of the leading causes of death and disability in
Europe and worldwide. For patients with multi-vessel CAD, coronary artery bypass graft …