Eight G protein‐coupled P2Y receptor subtypes respond to extracellular adenine and uracil
mononucleotides and dinucleotides. P2Y receptors belong to the δ group of rhodopsin‐like …

G-protein-coupled receptors (GPCRs) have been tractable drug targets for decades with
over one-third of currently marketed drugs targeting GPCRs. Of these, the class A GPCR …

A bifunctional imidazolium functionalized zirconium metal–organic framework (Zr-MOF),(I−)
Meim-UiO-66 (2), was successfully prepared from the imidazole-containing Zr-MOF Im-UiO …

G-protein-coupled receptors (GPCRs) are the largest class of signaling receptors that are
most frequently targeted by therapeutic drugs. Allosteric modulators bound to GPCRs at …

Highlights•GPCRs are key players in cell-cell communication and pass the signal via
coordinated action of switches.•There are two types of switches: toggle switches and …

G protein-coupled receptors (GPCRs), the largest family of human membrane proteins and
an important class of drug targets, play a role in maintaining numerous physiological …

Abstract P2Y receptors are G-protein-coupled receptors (GPCRs) for extracellular
nucleotides. There are eight mammalian P2Y receptor subtypes divided into two subgroups …

Many central biological events rely on protein–ligand interactions. The identification and
characterization of protein-binding sites for ligands are crucial for the understanding of …

The full activation process of G protein–coupled receptor (GPCR) plays an important role in
cellular signal transduction. However, it remains challenging to simulate the whole process …

Pain is both a major clinical and economic problem, affecting more people than diabetes,
heart disease, and cancer combined. While a variety of prescribed or over-the-counter …