Physical exercise as an epigenetic modulator of brain plasticity and cognition

J Fernandes, RM Arida, F Gomez-Pinilla - Neuroscience & Biobehavioral …, 2017 - Elsevier
A large amount of evidence has demonstrated the power of exercise to support cognitive
function, the effects of which can last for considerable time. An emerging line of scientific …

Behavioural phenotyping assays for mouse models of autism

JL Silverman, M Yang, C Lord… - Nature Reviews …, 2010 - nature.com
Autism is a heterogeneous neurodevelopmental disorder of unknown aetiology that affects 1
in 100–150 individuals. Diagnosis is based on three categories of behavioural criteria …

Genes, circuits, and precision therapies for autism and related neurodevelopmental disorders

M Sahin, M Sur - Science, 2015 - science.org
BACKGROUND Neurodevelopmental disorders are caused by abnormalities in the
developing brain. Such abnormalities can occur as a result of germline or somatic mutations …

MicroRNAs in neuronal function and dysfunction

HI Im, PJ Kenny - Trends in neurosciences, 2012 - cell.com
MicroRNAs (miRNAs) are small noncoding RNA transcripts expressed throughout the brain
that can regulate neuronal gene expression at the post-transcriptional level. Here, we …

Partial reversal of Rett Syndrome-like symptoms in MeCP2 mutant mice

D Tropea, E Giacometti, NR Wilson… - Proceedings of the …, 2009 - National Acad Sciences
Rett Syndrome (RTT) is a severe form of X-linked mental retardation caused by mutations in
the gene coding for methyl CpG-binding protein 2 (MECP2). Mice deficient in MeCP2 have a …

Clinical and biological progress over 50 years in Rett syndrome

H Leonard, S Cobb, J Downs - Nature Reviews Neurology, 2017 - nature.com
In the 50 years since Andreas Rett first described the syndrome that came to bear his name,
and is now known to be caused by a mutation in the methyl-CpG-binding protein 2 (MECP2) …

MeCP2 controls BDNF expression and cocaine intake through homeostatic interactions with microRNA-212

HI Im, JA Hollander, P Bali, PJ Kenny - Nature neuroscience, 2010 - nature.com
The X-linked transcriptional repressor methyl CpG binding protein 2 (MeCP2), known for its
role in the neurodevelopmental disorder Rett syndrome, is emerging as an important …

Environmental enrichment and brain repair: harnessing the therapeutic effects of cognitive stimulation and physical activity to enhance experience‐dependent …

AJ Hannan - Neuropathology and applied neurobiology, 2014 - Wiley Online Library
Environmental enrichment (EE) increases levels of novelty and complexity, inducing
enhanced sensory, cognitive and motor stimulation. In wild‐type rodents, EE has been found …

Nurturing brain plasticity: impact of environmental enrichment

L Baroncelli, C Braschi, M Spolidoro… - Cell Death & …, 2010 - nature.com
Environmental enrichment (EE) is known to profoundly affect the central nervous system
(CNS) at the functional, anatomical and molecular level, both during the critical period and …

The epigenome in neurodevelopmental disorders

J Reichard, G Zimmer-Bensch - Frontiers in Neuroscience, 2021 - frontiersin.org
Neurodevelopmental diseases (NDDs), such as autism spectrum disorders, epilepsy, and
schizophrenia, are characterized by diverse facets of neurological and psychiatric …