Physical exercise as an epigenetic modulator of brain plasticity and cognition
J Fernandes, RM Arida, F Gomez-Pinilla - Neuroscience & Biobehavioral …, 2017 - Elsevier
A large amount of evidence has demonstrated the power of exercise to support cognitive
function, the effects of which can last for considerable time. An emerging line of scientific …
function, the effects of which can last for considerable time. An emerging line of scientific …
Behavioural phenotyping assays for mouse models of autism
JL Silverman, M Yang, C Lord… - Nature Reviews …, 2010 - nature.com
Autism is a heterogeneous neurodevelopmental disorder of unknown aetiology that affects 1
in 100–150 individuals. Diagnosis is based on three categories of behavioural criteria …
in 100–150 individuals. Diagnosis is based on three categories of behavioural criteria …
Genes, circuits, and precision therapies for autism and related neurodevelopmental disorders
BACKGROUND Neurodevelopmental disorders are caused by abnormalities in the
developing brain. Such abnormalities can occur as a result of germline or somatic mutations …
developing brain. Such abnormalities can occur as a result of germline or somatic mutations …
MicroRNAs in neuronal function and dysfunction
MicroRNAs (miRNAs) are small noncoding RNA transcripts expressed throughout the brain
that can regulate neuronal gene expression at the post-transcriptional level. Here, we …
that can regulate neuronal gene expression at the post-transcriptional level. Here, we …
Partial reversal of Rett Syndrome-like symptoms in MeCP2 mutant mice
Rett Syndrome (RTT) is a severe form of X-linked mental retardation caused by mutations in
the gene coding for methyl CpG-binding protein 2 (MECP2). Mice deficient in MeCP2 have a …
the gene coding for methyl CpG-binding protein 2 (MECP2). Mice deficient in MeCP2 have a …
Clinical and biological progress over 50 years in Rett syndrome
In the 50 years since Andreas Rett first described the syndrome that came to bear his name,
and is now known to be caused by a mutation in the methyl-CpG-binding protein 2 (MECP2) …
and is now known to be caused by a mutation in the methyl-CpG-binding protein 2 (MECP2) …
MeCP2 controls BDNF expression and cocaine intake through homeostatic interactions with microRNA-212
The X-linked transcriptional repressor methyl CpG binding protein 2 (MeCP2), known for its
role in the neurodevelopmental disorder Rett syndrome, is emerging as an important …
role in the neurodevelopmental disorder Rett syndrome, is emerging as an important …
Environmental enrichment and brain repair: harnessing the therapeutic effects of cognitive stimulation and physical activity to enhance experience‐dependent …
AJ Hannan - Neuropathology and applied neurobiology, 2014 - Wiley Online Library
Environmental enrichment (EE) increases levels of novelty and complexity, inducing
enhanced sensory, cognitive and motor stimulation. In wild‐type rodents, EE has been found …
enhanced sensory, cognitive and motor stimulation. In wild‐type rodents, EE has been found …
Nurturing brain plasticity: impact of environmental enrichment
L Baroncelli, C Braschi, M Spolidoro… - Cell Death & …, 2010 - nature.com
Environmental enrichment (EE) is known to profoundly affect the central nervous system
(CNS) at the functional, anatomical and molecular level, both during the critical period and …
(CNS) at the functional, anatomical and molecular level, both during the critical period and …
The epigenome in neurodevelopmental disorders
J Reichard, G Zimmer-Bensch - Frontiers in Neuroscience, 2021 - frontiersin.org
Neurodevelopmental diseases (NDDs), such as autism spectrum disorders, epilepsy, and
schizophrenia, are characterized by diverse facets of neurological and psychiatric …
schizophrenia, are characterized by diverse facets of neurological and psychiatric …