Evidence obtained over the past two decades shows that reactive oxygen species (ROS) are
involved in brain lesions, including those due to cerebral ischemia-reperfusion. The …

Mitochondria are multifunctional and dynamic organelles deeply integrated into cellular
physiology and metabolism. Disturbances in mitochondrial function are involved in several …

Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels that mediate
synaptic transmission in the muscle and autonomic ganglia and regulate transmitter release …

The biology of the mitochondrial electron transport chain is summarized. Our approach to
the mechanism of uncouplers, inhibitors, and toxins is based on electron transfer (ET) and …

Activation of neuronal nicotinic acetylcholine receptors (nAChRs) has been shown to
maintain cognitive function following aging or the development of dementia. Nicotine and …

Huntington's disease (HD), a neurodegenerative disease, normally starts in the prime of
adult life, followed by a gradual occurrence of characteristic psychiatric disturbances and …

Nicotinic acetylcholine receptors (nAChRs) have long been considered to solely mediate
neurotransmission. However, their widespread distribution in the human body suggests a …

Cigarette smoke (CS)-induced alveolar destruction and energy metabolism changes are
known contributors to the pathophysiology of chronic obstructive pulmonary disease …

Chronic vascular hypoperfusion induces oxidative stress and brain energy failure, and leads
to neuronal death, which manifests as cognitive impairment and the development of brain …

Reactive oxygen species (ROS) are produced in many normal and abnormal processes in
humans, including atheroma, asthma, joint diseases, cancer, and aging. Basal levels of ROS …