The crosstalk between autophagy and apoptosis was mediated by phosphorylation of Bcl-2 and beclin1 in benzene-induced hematotoxicity

Y Chen, W Zhang, X Guo, J Ren, A Gao - Cell death & disease, 2019 - nature.com
Increasing evidence suggested that benzene exposure resulted in different types of
hematological cancer. Both autophagy and apoptosis were reported to play vital roles in …

The shape of low-concentration dose–response functions for benzene: implications for human health risk assessment

LA Cox Jr, HB Ketelslegers… - Critical Reviews in …, 2021 - Taylor & Francis
Are dose–response relationships for benzene and health effects such as myelodysplastic
syndrome (MDS) and acute myeloid leukemia (AML) supra-linear, with disproportionately …

Interventional probability of causation (IPoC) with epidemiological and partial mechanistic evidence: benzene vs. formaldehyde and acute myeloid leukemia (AML)

LA Cox Jr, WJ Thompson, KA Mundt - Critical Reviews in …, 2024 - Taylor & Francis
Introduction Causal epidemiology for regulatory risk analysis seeks to evaluate how
removing or reducing exposures would change disease occurrence rates. We define …

Genotoxicity of inhalational anesthetics and its relationship with the polymorphisms of GSTT1, GSTM1, and GSTP1 genes

F Kargar Shouroki, M Neghab, H Mozdarani… - … Science and Pollution …, 2019 - Springer
Due to their wide applications, concern exists regarding possible genotoxic effects of
inhalational anesthetics (IAs) among operating room personnel. This study was undertaken …

Generation characteristics and spreading risk of VOCs released from a biological fermentation pharmaceutical factory

Y Wang, H Song, L Li, J Ma, F Yu - Environmental Science: Processes …, 2023 - pubs.rsc.org
Pharmaceutical factories produce a large amount of volatile organic compounds (VOCs),
which may pose a potential health threat to the environment, workers, and nearby residents …

Ligand-independent activation of AhR by hydroquinone mediates benzene-induced hematopoietic toxicity

X Yang, C Li, G Yu, L Sun, S Guo, L Sai, C Bo… - Chemico-biological …, 2022 - Elsevier
Although it has been well recognized that benzene exposure can cause hematopoietic
disorders such as aplastic anemia and leukemia, the underlying molecular mechanism …

Endosulfan exposure alters transcription of genes involved in the detoxification and stress responses in Physella acuta

M Alonso-Trujillo, AB Muñiz-González… - Scientific Reports, 2020 - nature.com
Endosulfan is a persistent pesticide that has been in use for more than five decades. During
this time, it has contaminated soil, air, and water reservoirs worldwide. It is extremely toxic …

Hypermethylation in gene promoters are induced by chronic exposure to benzene, toluene, ethylbenzene and xylenes

RT Silvestre, M Bravo, F Santiago, L Delmonico… - 2020 - ninho.inca.gov.br
Background and Objective: Gas station attendants are occupationally exposed to benzene,
toluene, ethylbenzene and xylene (BTEX) compounds and thus more susceptible to the …

Influence of GSTM1, T1 genes polymorphisms on oxidative stress and liver enzymes in rural and urban pesticides-exposed workers

A Saad-Hussein, EM Shahy, KS Ibrahim… - … of Environmental & …, 2022 - Taylor & Francis
Several studies discussed the relationship between the toxicity of organophosphates (OPs)
and carbamates pesticides and oxidative stress which affects human health. This study …

Genetic variations in ATM and H2AX loci contribute to risk of hematological abnormalities in individuals exposed to BTEX chemicals

S Jafari Roshan, Y Mansoori… - Journal of Clinical …, 2022 - Wiley Online Library
Background Loci controlling DNA double‐strand breaks (DSBs) repair play an important role
in defending against the harmful health effects of benzene, toluene, ethylbenzene, and …