Hfq and other Sm proteins are central in RNA metabolism, forming an evolutionarily
conserved family that plays key roles in RNA processing in organisms ranging from archaea …

The small β-barrel (SBB) is an ancient protein structural domain characterized by extremes:
it features a broad range of structural varieties, a deeply intricate evolutionary history, and it …

Undergraduate biochemistry laboratory courses often do not provide students with an
authentic research experience, particularly when the express purpose of the laboratory is …

Background Protein–protein interactions have pivotal roles in life processes, and aberrant
interactions are associated with various disorders. Interaction site identification is key for …

The ability to assign function to proteins has become a major bottleneck for comprehensively
understanding cellular mechanisms at the molecular level. Here we discuss the extent to …

We suspect that there is a level of granularity of protein structure intermediate between the
classical levels of “architecture” and “topology,” as reflected in such phenomena as …

The Cry and Cyt classes of insecticidal toxins derived from the sporulating bacterium
Bacillus thuringiensis are valuable substitutes for synthetic pesticides in agricultural …

Sequence signature methods to analyze protein sequences have lately attracted the
attention of bioinformaticians and computational biologists. These methods are based on …

«L'esprit scientifique nous interdit d'avoir une opinion sur des questions que nous ne
comprenons pas, sur des questions que nous ne savons pas formuler clairement. Avant tout …

The study of superfamilies of protein domains using a combination of structure, sequence
and function data provides insights into deep evolutionary history. In the present paper …