If" the connectome" represents a complete map of anatomical and functional connectivity in
the brain, it should also include glia. Glia define and regulate both the brain's anatomical …

Astrocytes express a plethora of G protein-coupled receptors (GPCRs) that are crucial for
shaping synaptic activity. Upon GPCR activation, astrocytes can respond with transient …

Cellular edema (cell swelling) is a principal component of numerous brain disorders
including ischemia, cortical spreading depression, hyponatremia, and epilepsy. Cellular …

Astrocytes and neurons have been shown to swell across a variety of different conditions,
including increases in extracellular potassium concentration (^[K+] o). The mechanisms …

Normal nervous system function is critically dependent on the balance of water and ions in
the extracellular space (ECS). Pathological reduction in brain interstitial osmolarity results in …

The sympathetic nervous system (SNS) accelerates heart rate, increases cardiac
contractility, and constricts resistance vessels. The activity of SNS efferent nerves is …

Rapid increases in cell volume reduce the size of the extracellular space (ECS) and are
associated with elevated brain tissue excitability. We recently demonstrated that astrocytes …

Astrocytes and neurons have been shown to swell across a variety of different conditions,
including increases in extracellular potassium concentration (^[Kþ] o). The mechanisms …

Neurotransmitter and ion influx into astrocytes generates osmotic gradients coupled to water
movement into the cell, resulting in transient or prolonged fluctuations in cell volume …

Normal nervous system function is critically dependent on the balance of water and ions in
the extracellular space. Pathological reduction in brain interstitial osmolarity results in …