[HTML][HTML] CD4+ T cell depletion in human immunodeficiency virus (HIV) infection: role of apoptosis
M Février, K Dorgham, A Rebollo - Viruses, 2011 - ncbi.nlm.nih.gov
Human immunodeficiency virus (HIV) infection is principally a mucosal disease and the
gastrointestinal (GI) tract is the major site of HIV replication. Loss of CD4+ T cells and …
gastrointestinal (GI) tract is the major site of HIV replication. Loss of CD4+ T cells and …
[HTML][HTML] Focus: Infectious diseases: Mechanisms of virologic control and clinical characteristics of HIV+ elite/viremic controllers
E Gonzalo-Gil, U Ikediobi, RE Sutton - The Yale journal of biology …, 2017 - ncbi.nlm.nih.gov
Human immunodeficiency virus type 1 (HIV-1) disease is pandemic, with approximately 36
million infected individuals world-wide. For the vast majority of these individuals, untreated …
million infected individuals world-wide. For the vast majority of these individuals, untreated …
Low CCR5 expression protects HIV-specific CD4+ T cells of elite controllers from viral entry
M Claireaux, R Robinot, J Kervevan… - Nature …, 2022 - nature.com
HIV elite controllers maintain a population of CD4+ T cells endowed with high avidity for Gag
antigens and potent effector functions. How these HIV-specific cells avoid infection and …
antigens and potent effector functions. How these HIV-specific cells avoid infection and …
Relationships of PBMC microRNA expression, plasma viral load, and CD4+ T-cell count in HIV-1-infected elite suppressors and viremic patients
Background HIV-1-infected elite controllers or suppressors (ES) maintain undetectable viral
loads (< 50 copies/mL) without antiretroviral therapy. The mechanisms of suppression are …
loads (< 50 copies/mL) without antiretroviral therapy. The mechanisms of suppression are …
CCR5 revisited: how mechanisms of HIV entry govern AIDS pathogenesis
A Brelot, LA Chakrabarti - Journal of Molecular Biology, 2018 - Elsevier
The chemokine receptor CCR5 has been the focus of intensive studies since its role as a
coreceptor for HIV entry was discovered in 1996. These studies lead to the development of …
coreceptor for HIV entry was discovered in 1996. These studies lead to the development of …
Elite suppressors harbor low levels of integrated HIV DNA and high levels of 2-LTR circular HIV DNA compared to HIV+ patients on and off HAART
EH Graf, AM Mexas, JJ Yu, F Shaheen… - PLoS …, 2011 - journals.plos.org
Elite suppressors (ES) are a rare population of HIV-infected individuals that are capable of
naturally controlling the infection without the use of highly active anti-retroviral therapy …
naturally controlling the infection without the use of highly active anti-retroviral therapy …
Expression profile of host restriction factors in HIV-1 elite controllers
M Abdel-Mohsen, RAS Raposo, X Deng, M Li, T Liegler… - Retrovirology, 2013 - Springer
Background Several host-encoded antiviral factors suppress HIV-1 replication in a cell-
autonomous fashion in vitro. The relevance of these defenses to the control of HIV-1 in vivo …
autonomous fashion in vitro. The relevance of these defenses to the control of HIV-1 in vivo …
Restriction of HIV-1 replication in macrophages and CD4+ T cells from HIV controllers
A Sáez-Cirión, C Hamimi… - Blood, The Journal …, 2011 - ashpublications.org
How HIV controllers (HICs) maintain undetectable viremia without therapy is unknown. The
strong CD8+ T-cell HIV suppressive capacity found in many, but not all, HICs may contribute …
strong CD8+ T-cell HIV suppressive capacity found in many, but not all, HICs may contribute …
Elite controllers as a model of functional cure
B Autran, B Descours, V Avettand-Fenoel… - Current Opinion in …, 2011 - journals.lww.com
This review examines whether the exceptional HIV-infected elite controllers, who
spontaneously and durably maintain extremely low virus replication, might be considered as …
spontaneously and durably maintain extremely low virus replication, might be considered as …
Comprehensive analysis of unique cases with extraordinary control over HIV replication
D Mendoza, SA Johnson, BA Peterson… - Blood, The Journal …, 2012 - ashpublications.org
True long-term nonprogressors (LTNPs)/elite controllers (ECs) maintain durable control over
HIV replication without antiretroviral therapy. Herein we describe 4 unique persons who …
HIV replication without antiretroviral therapy. Herein we describe 4 unique persons who …