Highlights•Pyrazolotriazine is as an attractive scaffold for drug design development.•
Biological activity (in vitro and in vivo) of these derivatives are reviewed.•The SAR studies …

Guanine-based purines (GBPs) have been recently proposed to be not only metabolic
agents but also extracellular signaling molecules that regulate important functions in the …

Background Environmental pollutants, perfluorooctanoic acid (PFOA) and perfluorooctane
sulfonate (PFOS), are common surfactants in various consumer products. Epidemiological …

Purine nucleoside phosphorylase (PNP) activity is involved in cell survival and function,
since PNP is a key enzyme in the purine metabolic pathway where it catalyzes the …

Thyroid cancer is the most frequent endocrine tumor with a growing incidence worldwide.
However, common diagnostic strategy for thyroid cancer classification is hardly to make a …

In mammalian tissues under hypoxic conditions, ATP degradation results in accumulation of
purine metabolites. During exercise, muscle energetic demand increases and oxygen …

Marine mammals are exposed to ischemia/reperfusion and hypoxia/reoxygenation during
diving. During oxygen deprivation, adenosine triphosphate (ATP) breakdown implies purine …

Intracellular purine turnover is mainly oriented to preserving the level of triphosphate
nucleotides, fundamental molecules in vital cell functions that, when released outside cells …

Aquatic and semiaquatic mammals have the capacity of breath hold (apnea) diving.
Northern elephant seals (Mirounga angustirostris) have the ability to perform deep and long …

Purine nucleoside phosphorylase (PNP) is an ubiquitous enzyme which plays an important
role in arsenic (As) detoxification. As is a toxic metalloid present in air, soil and water; is …