Platelets are involved in the pathogenesis of vascular damage in both atherosclerosis and
arterial hypertension. Their reactivity in vivo is influenced by different factors, including …

Although there has been extensive research attempting to identify psychophysiologic
mechanisms linking psychological events and behavior patterns with risk for coronary heart …

Aspirin is proposed to be effective in stroke-prophylaxis because it completely inhibits the
platelet prostanoid-pathway. In about 90% of stroke victims, increased platelet reactivity (PR) …

Uremic patients have an impaired platelet function that has been related to membrane
glycoprotein (GP) abnormalities. Using a perfusion system, we have studied the interaction …

Although it is generally acknowledged that serotonin (5-HT) is a weak agonist for human
platelets, recent information suggests an association between serotonergic mechanisms …

Fibulin-1 is a component of the extracellular matrix that surrounds vascular smooth muscle.
This observation, along with the recent finding that fibulin-1 can bind fibrinogen (J Biol Chem …

A defect in hemostasis has been repeatedly reported in patients with cirrhosis. However, the
nature of this defect has not been fully characterized. We explored adhesive and cohesive …

Dear Sir, The concept of aspirin resistance was born together with the observation that
aspirin can interfere with factors of the hemostatic system [1]. Indeed as early as 1966, Quick …

A parallel-plate perfusion chamber has been used to evaluate the contribution of the
adhesive membrane glycoprotein CD36 (GPIV) to platelet adhesion on type I collagen in …

In 18 anesthetized dogs with a 70% mechanically produced coronary artery stenosis, blood
flow measured with an electromagnetic flowmeter showed cyclical reductions in flow due to …