The diversified role of mitochondria in ferroptosis in cancer

Y Liu, S Lu, L Wu, L Yang, L Yang, J Wang - Cell death & disease, 2023 - nature.com
Ferroptosis is a form of regulated cell death induced by iron-dependent lipid peroxidation,
and it has been studied extensively since its discovery in 2012. Induced by iron overload …

Ferroptosis and NRF2: an emerging battlefield in the neurodegeneration of Alzheimer's disease

DJR Lane, B Metselaar, M Greenough… - Essays in …, 2021 - portlandpress.com
Ferroptosis is an iron-and lipid peroxidation-dependent cell death modality and emerging
evidence indicates that ferroptosis has great explanatory potential for neuronal loss and …

Creatine kinase B suppresses ferroptosis by phosphorylating GPX4 through a moonlighting function

K Wu, M Yan, T Liu, Z Wang, Y Duan, Y Xia, G Ji… - Nature cell …, 2023 - nature.com
Activation of receptor protein kinases is prevalent in various cancers with unknown impact
on ferroptosis. Here we demonstrated that AKT activated by insulin-like growth factor 1 …

GTP cyclohydrolase 1/tetrahydrobiopterin counteract ferroptosis through lipid remodeling

VAN Kraft, CT Bezjian, S Pfeiffer… - ACS central …, 2019 - ACS Publications
Ferroptosis is an iron-dependent form of regulated cell death linking iron, lipid, and
glutathione levels to degenerative processes and tumor suppression. By performing a …

Blockade of GCH1/BH4 axis activates ferritinophagy to mitigate the resistance of colorectal cancer to erastin-induced ferroptosis

Q Hu, W Wei, D Wu, F Huang, M Li, W Li… - Frontiers in cell and …, 2022 - frontiersin.org
Ferroptosis, a type of cell death triggered by excessive accumulation of iron-dependent lipid
peroxidation, possesses an excellent potential in cancer treatment. However, many …

Ferroptosis: regulation by competition between NRF2 and BACH1 and propagation of the death signal

H Nishizawa, M Yamanaka, K Igarashi - The FEBS journal, 2023 - Wiley Online Library
Ferroptosis is triggered by a chain of intracellular labile iron‐dependent peroxidation of cell
membrane phospholipids. Ferroptosis is important not only as a cause of ischaemic and …

[HTML][HTML] Radiation-induced skin injury: pathogenesis, treatment, and management

X Yang, H Ren, X Guo, C Hu, J Fu - Aging (Albany NY), 2020 - ncbi.nlm.nih.gov
Radiation-induced skin injury (RSI) refers to a frequently occurring complication of radiation
therapy. Nearly 90% of patients having received radiation therapy underwent moderate-to …

Tetrahydrobiopterin: Beyond its traditional role as a cofactor

T Eichwald, LB da Silva, AC Staats Pires, L Niero… - Antioxidants, 2023 - mdpi.com
Tetrahydrobiopterin (BH4) is an endogenous cofactor for some enzymatic conversions of
essential biomolecules, including nitric oxide, and monoamine neurotransmitters, and for the …

Recent antioxidative nanomaterials toward wound dressing and disease treatment via ROS scavenging

X He, J Xue, L Shi, Y Kong, Q Zhan, Y Sun, Q Zhang… - Materials Today …, 2022 - Elsevier
Reactive oxygen species (ROS), the main cause of many tissue damage and diseases, are
known to be significantly harmful to various biological components in cells, for example …

Ferroptosis in sepsis: the mechanism, the role and the therapeutic potential

L Xl, Z Gy, CN - Frontiers in Immunology, 2022 - frontiersin.org
Sepsis is a common critical illness in the Intensive care unit (ICU) and its management and
treatment has always been a major challenge in critical care medicine. The dysregulated …