The diversified role of mitochondria in ferroptosis in cancer
Ferroptosis is a form of regulated cell death induced by iron-dependent lipid peroxidation,
and it has been studied extensively since its discovery in 2012. Induced by iron overload …
and it has been studied extensively since its discovery in 2012. Induced by iron overload …
Ferroptosis and NRF2: an emerging battlefield in the neurodegeneration of Alzheimer's disease
DJR Lane, B Metselaar, M Greenough… - Essays in …, 2021 - portlandpress.com
Ferroptosis is an iron-and lipid peroxidation-dependent cell death modality and emerging
evidence indicates that ferroptosis has great explanatory potential for neuronal loss and …
evidence indicates that ferroptosis has great explanatory potential for neuronal loss and …
Creatine kinase B suppresses ferroptosis by phosphorylating GPX4 through a moonlighting function
K Wu, M Yan, T Liu, Z Wang, Y Duan, Y Xia, G Ji… - Nature cell …, 2023 - nature.com
Activation of receptor protein kinases is prevalent in various cancers with unknown impact
on ferroptosis. Here we demonstrated that AKT activated by insulin-like growth factor 1 …
on ferroptosis. Here we demonstrated that AKT activated by insulin-like growth factor 1 …
GTP cyclohydrolase 1/tetrahydrobiopterin counteract ferroptosis through lipid remodeling
VAN Kraft, CT Bezjian, S Pfeiffer… - ACS central …, 2019 - ACS Publications
Ferroptosis is an iron-dependent form of regulated cell death linking iron, lipid, and
glutathione levels to degenerative processes and tumor suppression. By performing a …
glutathione levels to degenerative processes and tumor suppression. By performing a …
Blockade of GCH1/BH4 axis activates ferritinophagy to mitigate the resistance of colorectal cancer to erastin-induced ferroptosis
Q Hu, W Wei, D Wu, F Huang, M Li, W Li… - Frontiers in cell and …, 2022 - frontiersin.org
Ferroptosis, a type of cell death triggered by excessive accumulation of iron-dependent lipid
peroxidation, possesses an excellent potential in cancer treatment. However, many …
peroxidation, possesses an excellent potential in cancer treatment. However, many …
Ferroptosis: regulation by competition between NRF2 and BACH1 and propagation of the death signal
H Nishizawa, M Yamanaka, K Igarashi - The FEBS journal, 2023 - Wiley Online Library
Ferroptosis is triggered by a chain of intracellular labile iron‐dependent peroxidation of cell
membrane phospholipids. Ferroptosis is important not only as a cause of ischaemic and …
membrane phospholipids. Ferroptosis is important not only as a cause of ischaemic and …
[HTML][HTML] Radiation-induced skin injury: pathogenesis, treatment, and management
X Yang, H Ren, X Guo, C Hu, J Fu - Aging (Albany NY), 2020 - ncbi.nlm.nih.gov
Radiation-induced skin injury (RSI) refers to a frequently occurring complication of radiation
therapy. Nearly 90% of patients having received radiation therapy underwent moderate-to …
therapy. Nearly 90% of patients having received radiation therapy underwent moderate-to …
Tetrahydrobiopterin: Beyond its traditional role as a cofactor
T Eichwald, LB da Silva, AC Staats Pires, L Niero… - Antioxidants, 2023 - mdpi.com
Tetrahydrobiopterin (BH4) is an endogenous cofactor for some enzymatic conversions of
essential biomolecules, including nitric oxide, and monoamine neurotransmitters, and for the …
essential biomolecules, including nitric oxide, and monoamine neurotransmitters, and for the …
Recent antioxidative nanomaterials toward wound dressing and disease treatment via ROS scavenging
Reactive oxygen species (ROS), the main cause of many tissue damage and diseases, are
known to be significantly harmful to various biological components in cells, for example …
known to be significantly harmful to various biological components in cells, for example …
Ferroptosis in sepsis: the mechanism, the role and the therapeutic potential
L Xl, Z Gy, CN - Frontiers in Immunology, 2022 - frontiersin.org
Sepsis is a common critical illness in the Intensive care unit (ICU) and its management and
treatment has always been a major challenge in critical care medicine. The dysregulated …
treatment has always been a major challenge in critical care medicine. The dysregulated …